Mathematical rules for synergistic,additive,and antagonistic effects of multi-drug combinations and their application in research and development of combinatorial drugs and special medical food combinations  

作　　者：Shoujun Yuan Haoyu Chen 

机构地区：[1]Beijing Institute of Radiation Medicine,Academy of Military Medical Sciences(AMMS),Beijing 100850,China [2]Beijing Brightshines Technology Co.Ltd.,China

出　　处：《Food Science and Human Wellness》2019年第2期136-141,共6页食品科学与人类健康（英文）

摘　　要：Multi-drug(or multi-element)combinations are often prescribed in the practice of clinical medicine and as foods for special medical purposes.The main motivations for these combinations are that most diseases contain multiple related targets and an appropriate combination can maximize benefits while minimizing adverse reactions.As such,it is especially important to derive mathematical models for their quantitative calculation.In this paper,we introduce mathematical rules for the synergistic,additive,and antagonistic effects of multi-drug combinations developed in our laboratory.We have established a“onebelt,one-line”model and provide examples of the quantitative calculation of the synergistic,additive,and antagonistic effects of a combination of multiple components.We also explain how to scientifically and precisely determine the intensity of these synergies,additions and antagonisms,as well as their corresponding dose ranges,thereby laying a solid theoretical foundation for market listing combinatorial drugs and foods for special medical purposes.

关 键 词：Multi-drug combination Dose-effect belt One-belt one-line model Foods for special medical purposes Synergy Addition ANTAGONISM 

分 类 号：O29[理学—应用数学] TQ460.1[理学—数学] TS218[化学工程—制药化工]