ANTAGONISM

作品数：131被引量：308H指数：8
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Lubrication antagonism mechanism of nano-MoS_(2)and soot particles in ester base oil
《Friction》2024年第12期2692-2706,共15页Chonglong ZHONG Kunhong HU Yong XU Enzhu HU Xianguo HU 
supported by the National Natural Science Foundation of China(No.52075144);the Natural Science Foundation for Colleges and Universities in Anhui Province(No.2022AH010096).
Spherical nano-MoS_(2)(S-MoS_(2))has excellent lubricating properties and potential application value in engine oil additives.Engine soot can enter the engine oil,so the tribological interaction between S-MoS_(2)and d...
关键词：MoS_(2) nanoparticles tribological properties SOOT lubricant additive 
PBPK-PD model for predicting morphine pharmacokinetics,CNS effects and naloxone antagonism in humans
《Acta Pharmacologica Sinica》2024年第8期1752-1764,共13页Rui-jing Mu Tian-lei Liu Xiao-dong Liu Li Liu 
supported by the National Key Research and Development Program of China(Grant No.2022YFC3300902).
Morphine and morphine-6-glucuronide(M6G)produce central nervous system(CNS)effects by activating mu-opioid receptors,while naloxone is used mainly for the reversal of opioid overdose,specifically for the fatal complic...
关键词：MORPHINE NALOXONE PBPK-PD model MIOSIS respiratory depression ANALGESIA 
Remodeling the immune microenvironment for gastric cancer therapy through antagonism of prostaglandin E2 receptor 4
《Genes & Diseases》2024年第4期411-425,共15页Mengmeng Guo Pan Hu Jiayi Xie Kefu Tang Shixiu Hu Jialiang Sun Yundong He Jing Li Weiqiang Lu Huirong Liu Mingyao Liu Zhengfang Yi Shihong Peng 
supported by the National Natural Science Foundation of China(No.82073310 to Z.Yi,81830083 to M.Liu,81802970 to S.P.);the National Key R&D Program of China(No.2018YFA0507001 to M.Liu);The Science and Technology Commission of Shanghai Municipality,China(No.20JC1417900 to Z.Yi,22QB1405600 to S.P);ECNU Construction Fund of Innovation and Entrepreneurship Laboratory(Shanghai,China)(No.44400-20201-532300/021 to Z.Yi);ECNU Public Platform for innovation(Shanghai,China)(011 to S.P),and Pujiang Scholar Program Award(Shanghai,China)(No.22PJ1402700 to Y.H).
Gastric cancer is highly prevalent among digestive tract tumors.Due to the intri-cate nature of the gastric cancer immune microenvironment,there is currently no effective treatment available for advanced gastric cance...
关键词：EP4 IMMUNOMODULATION SYNERGY Tumor microenvironment YY001 
Antagonism effect of residual S triggers the dual-path mechanism for water oxidation被引量：1
《Journal of Energy Chemistry》2024年第6期568-579,I0014,共13页Li Liu Jinming Cao Siqi Hu Tinghui Liu Can Xu Wensheng Fu Xinguo Ma Xiaohui Yang 
supported by the Science and Technology Research Program of Chongqing Municipal Education Commission(KJQN202200550);the Natural Science Foundation Joint Fund for Innovation and Development of Chongqing Municipal Education Commission(CSTB2022NSCQ-LZX0077);the National Natural Science Foundation of China(No.52100065);the Science and Technology Research Program of Natural Science Foundation of Chongqing(cstc2021ycjh-bgzxm0037);the Science and Technology Research Program of Chongqing Municipal Education Commission(KJZD-M202200503);the Chongqing Innovation Research Group Project(No.CXQT21015);the Doctor Start/Talent Introduction Program of Chongqing Normal University(No.02060404/2020009000321)。
Transition metal chalcogenides(TMCs)are recognized as pre-catalysts,and their(oxy)hydroxides derived from electrochemical reconstruction are the active species in the water oxidation.However,understanding the role of ...
关键词：Electrochemical reconstruction Adsorbate evolution mechanism Lattice oxygen oxidation mechanism Oxygen evolution reaction Residual sulfur 
Fecal microbiota transplantation in clinical practice:Present controversies and future prospects
《hLife》2024年第6期269-283,共15页Hongliang Tian Xinjun Wang Zhixun Fang Long Li Chunyan Wu Dexi Bi Ning Li Qiyi Chen Huanlong Qin 
This study was supported by the National NaturalScience Foundation of China(81972221,81730102,and 82300753);China postdoctoral science foundation(2022M722412);Top priority project of Shanghai(076478684Q/2023-00154);Major project of Zhangjiang(ZJ2022-ZD-005);Clinical Research Plan of SHDC(SHDC2020CR4026,SHDC2020CR1030B,and SHDC2022CRS041);Project of Shanghai Science and Technology Commission(YDZX20213100003690);Project of Shanghai Municipal Health Commission(19YF1431000 and ZHYY-ZXYJHZX-202105);Anhui Provincial Key R&D Programmes(202304295107020025);Climb Plan of Tenth People’s Hospital of Tongji University(2021SYPDRC045).
The gut microbiota,serving as the only“organ”that humans can share,has been extensively applied in the treatment of various intestinal and extraintestinal diseases through fecal microbiota transplantation(FMT)techno...
关键词：fecal microbiota transplantation clinical research colonization antagonism 
Structural insight into the dual-antagonistic mechanism of AB928 on adenosine A_(2)receptors
《Science China(Life Sciences)》2024年第5期986-995,共10页Yuan Weng Xinyu Yang Qiansen Zhang Ying Chen Yueming Xu Chenyu Zhu Qiong Xie Yonghui Wang Huaiyu Yang Mingyao Liu Weiqiang Lu Gaojie Song 
supported by the National Key Research and Development Program of China(2018YFA0507001);the Basic Research Program of Science and Technology Commission of Shanghai Municipality(21JC1402400);the National Natural Science Foundation of China(32171215,81972828,82172644,82273857 and 81830083);the National Key Scientific Infrastructure for Translational Medicine(Shanghai)(TMSK-2021-120)。
The adenosine subfamily G protein-coupled receptors A_(2A)R and A_(2B)R have been identified as promising cancer immunotherapy candidates.One of the A_(2A)R/A_(2B)R dual antagonists,AB928,has progressed to a phaseⅡcl...
关键词：adenosine receptor A2AR A2BR INHIBITOR dual-antagonism drug discovery 
Natural polysaccharide-based smart CXCR4-targeted nano-system for magnified liver fibrosis therapy被引量：1
《Chinese Chemical Letters》2024年第2期341-346,共6页Liqiong Sun Xinping Luo Chenxi Zhou Zhanwei Zhou Minjie Sun 
financially supported by the Jiangsu Agriculture Science and Technology Innovation Fund(No.CX(22)3174);the National Natural Science Foundation of China(No.82102202);Natural Science Foundation of Jiangsu Province(No.BK20210424);Postgraduate Research&Practice Innovation Program of Jiangsu Province(No.KYCX23_0849).
Activated hepatic stellate cells(aHSCs),the main source of extracellular matrix deposition,are key targets in liver fibrosis.However,no effective drug specific to aHSCs has been clinically applied due to poor drug del...
关键词：Nanoparticle CXCR4 antagonism ROS-responsive Hepatic stellate cells Liver fibrosis 
Mutual antagonism of mouse-adaptation mutations in HA and PA proteins on H9N2 virus replication被引量：2
《Virologica Sinica》2024年第1期56-70,共15页Liping Ma Huabin Zheng Xianliang Ke Rui Gui Zhongzi Yao Jiasong Xiong Quanjiao Chen 
supported by the National Key Research and Development Program of China(NKPs)(2022YFC2604101);the National Science and Technology Major Project of China(2020ZX10001016-002)。
Avian H9N2 viruses have wide host range among the influenza A viruses.However,knowledge of H9N2 mammalian adaptation is limited.To explore the molecular basis of the adaptation to mammals,we performed serial lung pass...
关键词：Influenza Avirus(IAV) H9N2 HA PA ANTAGONISM Mouse adaptation 
Design and synthesis of tri-substituted pyrimidine derivatives as bifunctional tumor immunotherapeutic agents targeting both A2A adenosine receptors and histone deacetylases
《Chinese Chemical Letters》2024年第1期295-299,共5页Ruiquan Liu Wenwen Duan Wenzhong Yan Jinfeng Zhang Jianjun Cheng 
Lingang Laboratory(No.LG-QS-202205-03);ShanghaiTech University and the Shanghai Municipal Government.
The A_(2A)adenosine receptor(A_(2A)AR)has attracted attention as an emerging immunotherapeutic target with several antagonists being evaluated in clinical trials.However,A_(2A)AR antagonists show limited efficacy as m...
关键词：BIFUNCTIONAL A_(2A)AR antagonism HDAC inhibition Cancer IMMUNOTHERAPY 
Comparison of internal force antagonism between redundant cable-driven parallel robots and redundant rigid parallel robots
《Frontiers of Mechanical Engineering》2023年第4期97-117,共21页Yuheng WANG Xiaoqiang TANG 
the financial support of the National Natural Science Foundation of China(Grant No.51975307).
The internal force antagonism(IFA)problem is one of the most important issues limiting the applications and popularization of redundant parallel robots in industry.Redundant cable-driven parallel robots(RCDPRs)and red...
关键词：cable-driven parallel robots parallel robots redundant robots evaluation index force solution space 
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