Prophylactic effect of Kudingcha polyphenols on oxazolone induced colitis through its antioxidant capacities  

作　　者：Xingyao Long Yanni Pan Xin Zhao 

机构地区：[1]Chongqing Collaborative Innovation Center for Functional Food,Chongqing University of Education,Chongqing 400067,PR China [2]College of Food Science,Southwest University,Chongqing 400715,PR China [3]School of Biological and Chemical Engineering,Chongqing University of Education,Chongqing 400067,PR China

出　　处：《Food Science and Human Wellness》2018年第3期209-214,共6页食品科学与人类健康（英文）

基　　金：The present research was supported by the Program for Innovation Team Building at Institutions of Higher Education in Chongqing(CXTDX201601040);the Introduction of High-level Personnel Research Start-up Fund of Chongqing University of Education(2013BSRC001),China.

摘　　要：This research the preventive effect of Kudingcha polyphenols(Kp)on colitis based on animal experiments.Experimental mice divided into four groups,including normal group,model group,low-concentration Kp(LKP)group and high-concentration Kp(HKP)group,and they all smeared and given 0.15 mL 1%oxazolone solution by lavage to induce BALB/c mice colitis.DAI,colon weight/length ratio,serum levels of cytokines,related antioxidant activities of colon tissues such,and the mRNA expressions.The experimental results show that KP can significantly(p<0.05)reduce DAI in mice with colitis and inhibit shortening of colon caused by colitis,increase colon weight/length ratio.It can also significantly reduce(p<0.05)the activities of MPO,NO,MDA in mice colon tissues with colitis,increase the activity of GSH,and significantly increase(p<0.05)the level of IL-2 and decrease the level of IL-10 in mice serum with colitis.The results of qPCR assay show that Kp can significantly increase(p<0.05)the expression of Cu/Zn-SOD,Mn-SOD,GSH-Px,CAT,c-Kit,SCF and decrease the expression of IL-8,CXCR2 in mice colon tissues with colitis.Kp has a good preventive effect on colitis,and high concentration of PT has better preventive effect.

关 键 词：Kudingcha polyphenols OXAZOLONE ANTIOXIDANT COLITIS mRNA expression 

分 类 号：TS272.5[农业科学—茶叶生产加工]