茶叶有效成分对黑色素形成的抑制作用  

Inhibition of Active Compounds in Tea on Melanin Formation

作　　者：王蔚 陈琳[1,2] 王伟伟[1] 张建勇[1] 江和源[1] WANG Wei;CHEN Lin;WANG Weiwei;ZHANG Jianyong;JIANG Heyuan(Tea Research Institute,Chinese Academy of Agricultural Sciences,Key Laboratory of Tea Plants Biology and Resources Utilization of Agriculture Ministry,Key Laboratory of Tea Processing Engineering of Zhejiang Province,Hangzhou 310008,China;Graduate School of Chinese Academy of Agricultural Sciences,Beijing 100081,China)

机构地区：[1]中国农业科学院茶叶研究所农业部茶树生物学与资源利用重点实验室浙江省茶叶加工工程重点实验室,浙江杭州310008 [2]中国农业科学院研究生院,北京100081

出　　处：《茶叶科学》2021年第1期7-18,共12页Journal of Tea Science

基　　金：国家自然科学基金(31670692);国家重点研发计划项目(2017YFD04008);中国农业科学院科技创新工程(CAAS-ASTIP-2020-TRICAAS)。

摘　　要：黑色素是一种高分子生物色素,皮肤的颜色由黑色素的合成类型、累积量、黑素小体的再分布及降解决定。太阳紫外线辐射是导致黑色素形成过多的最常见因素。黑色素虽能保护皮肤细胞免受紫外线损伤,但异常积累将会导致黑色素紊乱疾病的发生。因此开发绿色、安全、高效的植物来源的黑色素抑制剂成为近年来研究的热点。不少研究表明茶叶提取复合物或茶叶单体成分可明显降低酪氨酸酶活性,减缓黑色素细胞的生长增殖、浸润、转移,抑制皮肤癌发生等。通过对茶叶有效成分在非细胞酪氨酸酶测试系统、细胞测试系统、动物模型以及人体皮肤中抑制黑色素形成的研究进展进行综述,以期充分挖掘茶叶中主要有效成分抑制黑色素的形成及其相应的作用机制,开发一种安全高效的黑色素合成抑制剂,并为实现茶产品的综合利用、提高茶产业附加值提供思路。Melanin is a kind of high molecular biological pigment.The color of skin is determined by the type and accumulation of melanin as well as the redistribution and degradation of melanosome.Solar ultraviolet radiation is the most common cause of melanin formation.Although melanin can protect skin cells from UV damage,the abnormal accumulation of melanin will lead to diseases related with melanin disorders.Therefore,the development of green,safe and efficient melanin inhibitors extracted from plants has become a research hotspot in recent years.Many studies have proved that extract or monomer compounds of tea could significantly inhibit(a)the activity of tyrosinase,(b)the growth,proliferation,infiltration and metastasis of melanocytes,(c)the occurrence of skin cancer.In this paper,the research progress of tea active compounds inhibiting melanin formation in acellular tyrosinase test system,cell test system,animal model and human skin was reviewed to fully explore the key active compounds,find a safe and efficient inhibitor of melanin synthesis and provide reference for the comprehensive utilization of tea products and increasing the added value of tea industry.

关 键 词：茶叶有效成分 黑色素 非细胞酪氨酸酶测试系统 细胞测试系统 动物模型 人体皮肤 

分 类 号：S571[农业科学—作物学] Q946.841[生物学—植物学]