慢性胰腺炎患者胰腺外分泌功能不全诊治现状  

Pancreatic exocrine insufficiency in chronic pancreatitis patients:diagnosis and treatment

作　　者：刘雨[1,2] 胡良皞 LIU Yu;HU Liang-hao(Department of Gastroenterology,Changhai Hospital,Naval Medical University(Second Military Medical University),Shanghai 200433,China;Department of Gastroenterology,General Hospital of PLA Eastern Theater Command,Nanjing 210002,Jiangsu,China)

机构地区：[1]海军军医大学(第二军医大学)长海医院消化内科,上海200433 [2]中国人民解放军东部战区总医院消化内科,南京210002

出　　处：《第二军医大学学报》2021年第2期203-208,共6页Academic Journal of Second Military Medical University

基　　金：国家自然科学基金(81470883,81770635);上海市青年科技启明星计划(17QA1405500);上海青年拔尖人才开发计划(HZW2016FZ67);上海市卫生和计划生育委员会智慧医疗专项科研项目(2018ZHYL0229).

摘　　要：慢性胰腺炎继发胰腺外分泌功能不全(PEI)严重影响患者的生活质量。PEI目前尚无单一的、可广泛应用的诊断方法,需根据患者的临床表现、胰腺外分泌功能、营养状态等多方面综合考虑做出诊断。PEI的主要治疗方法为胰酶替代治疗(PERT),此外还需配合营养状态改善和生活方式调整。PERT过程中应通过观察患者的临床表现、检测血清营养物质含量等监测疗效,对于PERT疗效欠佳者需仔细分析原因以制订合理的对策。Pancreatic exocrine insufficiency(PEI)secondary to chronic pancreatitis seriously affects the quality of life of the patients.There is no single and widely used method for diagnosis of PEI.Diagnosis of PEI should be based on the clinical manifestations,pancreatic exocrine function tests,nutritional status and other aspects.Pancreatic enzyme replacement therapy(PERT)is the main treatment of PEI,which should be combined with improved nutritional status and lifestyle.Therapeutic effect should be monitored during PERT by observing the clinical manifestations,detecting the content of serum nutrients and so on.For the patients with poor prognosis after PERT,it is necessary to carefully analyze the causes to formulate a reasonable countermeasure.

关 键 词：慢性胰腺炎 胰腺外分泌功能不全 胰酶 酶替代治疗 

分 类 号：R576.2[医药卫生—消化系统]