食源性致病菌基因组数据平台建设与展望  

The Status and Development of Foodborne Pathogens Genome Data Platform

作　　者：刘冬梅 亓合媛[1] 刘杨 肖革新 LIU Dong-mei;QI He-yuan;LIU Yang(National Institute of Hospital Administration,NHC,Beijing 100044,P.R.C)

机构地区：[1]中国科学院微生物研究所,北京市朝阳区100101 [2]贵州科学院,贵州省贵阳市550001 [3]国家卫生健康委医院管理研究所,北京市海淀区100044

出　　处：《中国数字医学》2021年第1期83-87,共5页China Digital Medicine

基　　金：国家重点研发计划食品安全社会共治信息技术研究与应用示范项目-食品安全管控多维动态关联分析技术研究(编号:2017YFC1602002)。

摘　　要：在信息科学飞速发展、测序技术不断完善的今天,食源性致病菌溯源研究有了全新的基于全基因组测序的技术方法和分析手段,从食源性致病菌基因组序列中可以获得更多的遗传信息来支持科研人员做研究,进而辅助管理人员做决策。在食品安全管控方面,系统性地整合基因组数据、元数据和配套模型,搭建食源性致病菌基因组数据平台是十分有必要的。以食源性致病菌基因组数据平台建设的需求与发展方向出发,细致梳理数据集成和关联模型中可能存在的问题与部署方向,能够为平台建设提供详细的实施蓝图。With the rapid development of information and sequencing technology,there are some new approaches provided in the study on bacterial pathogens,which is the main role in foodborne disease.As the whole genome data can be used to illustrate the epidemiology of the outbreak and to compare variant loci of pathogen genomes between different groups.Then,the administrative department can make a better decision on the early warning and real-time control.Therefore,a bacterial pathogens genomic data platform,which integrates high-quality data including genomic data,sample metadata,and food chain network data,related models and analysis tools,is necessary for food safety control.Here,based on the review of the bacterial pathogens typing method,existing bacterial pathogens databases and associated analysis model,this paper illuminates the difficulties on data integration and the development of data platform.

关 键 词：食源性致病菌 分型 溯源 基因组数据平台 

分 类 号：R319[医药卫生—基础医学]