Intervertebral disc development and disease-related genetic polymorphisms  

作　　者：Jason W.Ashley Motomi Enomoto-Iwamoto Lachlan J.Smith Robert L.Mauck Danny Chan Joseph Lee Martin F.Heyworth Howard An Yejia Zhang 

机构地区：[1]Department of Orthopedic Surgery,Perelman School of Medicine,University of Pennsylvania,USA [2]Department of Surgery,Division of Orthopaedic Surgery,Children’s Hospital of Philadelphia,Philadelphia,PA,USA [3]School of Biomedical Sciences,The University of Hong Kong,Hong Kong [4]Department of Orthopedic Surgery,University of Chicago,Chicago,IL,USA [5]Corporal Michael J.Crescenz Veterans Affairs Medical Center,Philadelphia,PA,USA [6]Department of Medicine,Perelman School of Medicine,University of Pennsylvania,USA [7]Department of Orthopedic Surgery,Rush University Medical Center,Chicago,IL,USA [8]Department of Physical Medicine&Rehabilitation,Perelman School of Medicine,University of Pennsylvania,USA

出　　处：《Genes & Diseases》2016年第3期171-177,共7页基因与疾病（英文）

基　　金：Jason W.Ashley,PhD is supported by the University of Pennsylvania Postdoctoral Opportunities in Research and Teaching(PENN-PORT)fellowship funded by the National Institute of General Medical Sciences Institutional Research and Career Development Award(IRACDA;5 K12 GM081259-09);Yejia Zhang,MD,PhD has been supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development(NICHD,1K08 HD049598);This work is supported,in part,by research grants from the Department of Veterans Affairs(VA RR&D I01 RX001321 and VA1I21RX001896);the Research Grants Committee of Hong Kong(T-12-708/12N).

摘　　要：The intervertebral disc(IVD)comprises a gelatinous inner core(nucleus pulposus;NP)and concentric rings(annulus fibrosus;AF).The NP,an important structure for shock absorption in the vertebrate spinal motion segment,can be traced back to the notochord in ontogenetic lineage.In vertebrates,the notochord undergoes mucinoid changes,and had been considered vestigial until recently.However,observed correlations between IVD degeneration and back pain in humans have renewed interest in the IVD in biomedical fields.Beyond its mechanical contribution to development,the notochord is also an essential signaling center,which coordinates formation of the neural tube and somites.The pertinent signaling molecules,particularly TGF-b and bone morphogenetic proteins(BMPs),continue to play roles in the adult tissues and have been utilized for tissue regeneration.Genetic factors are major determinants of who will develop IVD degeneration and related back pain,and seem to correlate better with disc degeneration and back pain than do external forces on the spine.In summary,the spinal column is a landmark development in evolution.Genes directing the development of the IVD may also contribute to its maintenance,degeneration,and regeneration.Likewise,structural genes as well as genes responsible for maintenance of the structure are related to IVD degeneration.Finally,genes responsible for inflammation may play a dual role in exacerbating degeneration or facilitating repair responses depending on the context.

关 键 词：Back pain DEVELOPMENT Intervertebral disc(IVD) NOTOCHORD REGENERATION 

分 类 号：R59[医药卫生—内科学]