Evaluation on monoamine neurotransmitters changes in depression rats given with sertraline, meloxicam or/and caffeic acid  

作　　者：Dan Huang Lu Zhang Jun-qing Yang Ying Luo Ting Cui Ting-ting Du Xin-hui Jiang 

机构地区：[1]School of Pharmacy,Chongqing Medical University,Chongqing,400016,China [2]West China-Washington Mitochondria and Metabolism Center,West China Hospital/West China Medical School,Sichuan University,Chengdu 610041,China [3]Zunyi Medical and Pharmaceutical College,Zunyi,563006,China

出　　处：《Genes & Diseases》2019年第2期167-175,共9页基因与疾病（英文）

基　　金：supported by pharmacy school of Chongqing Medical University.This research work was financially supported by Research Fund of Chongqing Science&Technology Commission(No:cstc2013jcyjA10040);Research Start-up Fund of Pharmacy School of Chongqing Medical University.

摘　　要：Inflammation drives the development of depression and may affect neurotransmitters and thus neurocircuits increase the risk of depression.To investigate the influence of inhibition of inflammatory pathways on the biogenic amine neurotransmitters metabolism in depressive rats,sertraline,and meloxicam,the inhibitors of arachidonic acid-cyclooxygenase-2/lipoxygenase(AA-COX-2/5-LO)pathways,were given to depressive rats.After the development of depression model by chronic unpredictable mild stress(CUMS)for 6 weeks,Successful modeling rats were selected and randomly divided into CUMS group and medication administration group.After given medicine,The biogenic amine neurotransmitters in rat cortex and hippocampus were measured by high-performance liquid chromatography equipped with an electrochemical detector(HPLC-ECD).Compared with the normal group,the concentration of norepinephrine(NE)significantly decreased and the concentrations of Tyrosine(Tyr),Tryptophan(Trp),3,4-dihydroxyphenyl acetic acid(DOPAC),3-methoxy-4-hydroxyphenylglycol(MHPG),homovanillic acid(HVA)and 5-hydroxyindoleacetic acid(5-HIAA)significantly increased in the CUMS group.Sertraline significantly inhibited the elevation of 5-HIAA.Meloxicam inhibited the decrease of NE level in CUMS-induced rat and the increase of Trp,MHPG,and 5-HIAA level in a dose-dependent manner.Caffeic acid inhibited the decrease of NE and the increase of Trp and MHPG in a dose-dependent manner.The inhibition of AA-COX-2/5-LO pathways can improve the behaviors of depression rats and suppress CUMSinduced changes in biogenic amines.Compared with the single-dose lipoxygenase(5-LO)or Cyclooxygenase-2(COX-2)inhibitor,the combination treatment with meloxicam 1 mg/kg and caffeic acid 10 mg/kg have no significant improvement in CUMS-induced depression behavior and the level of cortical monoamine neurotransmitters and their metabolites.

关 键 词：AA-COX-2/5-LO inflammatory pathways Bioamine neurotransmitters Caffeic acid Depression rat MELOXICAM SERTRALINE 

分 类 号：R73[医药卫生—肿瘤]