The fuel and engine: The roles of reprogrammed metabolism in metastasis of primary liver cancer  

作　　者：Wen-Wei Zhu Ming Lu Xiang-Yu Wang Xu Zhou Chao Gao Lun-Xiu Qin 

机构地区：[1]Department of General Surgery,Huashan Hospital,Cancer Metastasis Institute,Fudan University,12 Urumqi Road(M),Shanghai,200040,China

出　　处：《Genes & Diseases》2020年第3期299-307,共9页基因与疾病（英文）

基　　金：This study was supported by National Major Science and Technology Projects of China(No.2017ZX10203207);National Natural Science Foundation of China(No.81472677).

摘　　要：Metastasis and metabolism reprogramming are two major hallmarks of cancer.In the initiation and progression of cancer,tumor cells are known to undergo fundamental metabolic changes to sustain their development and progression.In recent years,much more attentions have been drawn to their important roles in facilitating cancer metastasis through regulating the biological properties.In this review,we summarized the recent progresses in the studies of metabolism reprogramming of cancer metastasis,particularly of primary liver cancer,and highlight their potential applications.

关 键 词：Amino acid Cancer metastasis CHOLESTEROL Fatty acid GLUCOSE Primary liver cancer Tumor microenvironment 

分 类 号：R735.7[医药卫生—肿瘤]