The dual role of necrostatin-1 in Parkinson’s disease models  

作　　者：Eva Alegre-Cortes Guadalupe Martinez-Chacon Jose M.Fuentes Sokhna M.S.Yakhine-Diop 

机构地区：[1]Universidad de Extremadura,Depto.Bioquimica y Biologia Molecular y Genetica,Facultad de Enfermeria y Terapia Ocupacional,Avda de la Universidad s/n,Caceres,Spain [2]Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas(CIBERNED)Madrid,Spain [3]Instituto Universitario de Investigacion Biosanitaria de Extremadura(INUBE),Caceres,Spain

出　　处：《Neural Regeneration Research》2021年第10期2019-2020,共2页中国神经再生研究（英文版）

基　　金：This work was supported by grants from Junta de Extremadura,Spain,No.IB18048(to EAC),the ONCE Foundation(to GMC);the Isabel Gemio Foundation(to SMSYD);the Instituto de Salud Carlos III,CIBERNED,No.CB06/05/004(to JMF);partially supported by the“Fondo Europeo de Desarrollo Regional”(FEDER)from the European Union.

摘　　要：Neuronal cell death is the main hallmark of Parkinson’s disease(PD).It is an irreversible process promoted by neurotoxins and/or genetic mutations.Different types of cell death have been associated with PD.The mechanisms by which neurons decide to specific type of cell death remain elusive.However,it is well known that cell death can be either programmed or not.Apoptosis is a programmed cell death that involves the release of cytochrome c from damaged mitochondria to cytosol and the activation of caspases leading to nuclear condensation.Necrosis is a caspase-independent cell death characterized by a gain in cell volume,rupture of plasma membrane and leak of cell contents,inflammation,and affects neighbouring cells.It was classified as a nonprogrammed cell death,but there are types of necrotic death triggered by a protein activation cascade,including necroptosis.

关 键 词：INFLAMMATION NECROSIS RUPTURE 

分 类 号：R742.5[医药卫生—神经病学与精神病学]