Arbutin effectively ameliorates the symptoms of Parkinson’s disease:the role of adenosine receptors and cyclic adenosine monophosphate  

作　　者：Jie Zhao Manish Kumar Jeevan Sharma Zhihai Yuan 

机构地区：[1]Department of Neurology,Zhengzhou Central Hospital Affiliated to Zhengzhou University,Zhengzhou,Henan Province,China [2]Department of Pharmacology,Swift School of Pharmacy,Rajpura(Patiala),Punjab,India [3]Department of Neurosurgery,The Second Affiliated Hospital of Xi’an Medical University,Xi’an,Shaanxi Province,China

出　　处：《Neural Regeneration Research》2021年第10期2030-2040,共11页中国神经再生研究（英文版）

摘　　要：An antagonistic communication exists between adenosinergic and dopaminergic signaling in the basal ganglia,which suggests that the suppression of adenosine A2A receptors-cyclic adenosine monophosphate pathway may be able to restore the disrupted dopamine transmission that results in motor symptoms in Parkinson’s disease(PD).Arbutin is a natural glycoside that possesses antioxidant,antiinflammatory,and neuroprotective properties.The purpose of this study was to investigate whether arbutin could ameliorate the symptoms of PD and to examine the underlying mechanism.In this study,Swiss albino mouse models of PD were established by the intraperitoneal injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine for 4 successive days,with the concurrent intraperitoneal administration of arbutin(50 and 100 mg/kg)for 7 days.The results showed that arbutin significantly reduced lipid peroxidation,total nitrite levels,and inflammation in the substantia nigra and striatum of PD mouse models.In addition,arbutin decreased the activity of endogenous antioxidants,reduced the levels of dopamine,3,4-dihydroxyphenylacetic acid,homovanillic acid,andγ-aminobutyric acid,and minimized neurodegeneration in the striatum.Arbutin also reduced the abnormal performance of PD mouse models in the open field test,bar test,pole test,and rotarod test.The therapeutic efficacy of arbutin was similar to that of madopar.The intraperitoneal injection of the A2AR agonist CGS21680(0.5 mg/kg)attenuated the therapeutic effects of arbutin,whereas the intraperitoneal injection of forskolin(3 mg/kg)enhanced arbutin-mediated improvements.These findings suggest that arbutin can improve the performance of PD mouse models by inhibiting the function of the A2AR and enhancing the effects of cyclic adenosine monophosphate.This study was approved by the Institutional Animal Ethics Committee(1616/PO/Re/S/12/CPCSEA)on November 17,2019(approval No.IAEC/2019/010).

关 键 词：ARBUTIN CGS21680 DOPAMINE FORSKOLIN GABA inflammation oxidative stress Parkinson’s disease STRIATUM substantia nigra 

分 类 号：R285[医药卫生—中药学]