Advances in Drug Therapy for Alzheimer’s Disease  

作　　者：Chuan-cong ZHU Si-yu FU Yu-xin CHEN Ling LI Ruo-lin MAO Jian-zhi WANG Rong LIU Yi LIU Xiao-chuan WANG 

机构地区：[1]Department of Pathophysiology,School of Basic Medicine,Key Laboratory of Education Ministry of China for Neurological Disorders,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China [2]Co-innovation Center of Neuroregeneration,Nantong University,Nantong 226001,China [3]Department of Pathology and Pathophysiology,School of Medicine,Jianghan University,Wuhan 430056,China

出　　处：《Current Medical Science》2020年第6期999-1008,共10页当代医学科学（英文）

基　　金：This study was supported by the Ministry of Science and Technology of China(No.2016YFC1305800);the National Natural Science Foundation of China(No.31771114 and No.31929002);the Innovative Research Groups of the National Natural Science Foundation of China(No.81721005);the Academic Frontier Youth Team Project to Xiao-chuan WANG from Huazhong University of Science and Technology。

摘　　要：Alzheimer’s disease(AD)is a chronic neurodegenerative disease that mainly causes dementia.It is a serious threat to the health of the global elderly population.Considerable money and effort has been invested in the development of drug therapy for AD worldwide.Many drug therapies are currently under development or in clinical trials,based on two known mechanisms of AD,namely,Aβtoxicity and the abnormal Tau hyperphosphorylation.Numerous drugs are also being developed for other AD associated mechanisms such as neuroinflammation,neurotransmitter imbalance,oxidative damage and mitochondrial dysfunction,neuron loss and degeneration.Even so,the number of drugs that can successfully improve symptoms or delay the progression of the disease remains very limited.However,multi-drug combinations may provide a new avenue for drug therapy for AD.In addition,early diagnosis of AD and timely initiation of treatment may allow drugs that act on the early pathological processes of AD to help improve the symptoms and prevent the progression of the condition.

关 键 词：Alzheimer’s disease AΒ TAU drug therapy 

分 类 号：R74[医药卫生—神经病学与精神病学]