Adding Fuel to the Fire by Increased GABAergic Inhibition:A Seizure-Amplifying Nigra-Parafascicular Pathway  

作　　者：Yeping Ruan Rongrong Chen Jie Yu Chengping Wen Zhenghao Xu 

机构地区：[1]Zhejiang Chinese Medical University,Hangzhou 310053,China [2]School of Basic Medical Science,Zhejiang Chinese Medical University,Hangzhou 310053,China

出　　处：《Neuroscience Bulletin》2021年第1期135-137,共3页神经科学通报（英文版）

基　　金：funded by the National Natural Science Foundation of China(81673623);a project of the National Education Steering Committee for Postgraduate Students Majoring in Traditional Chinese Medicine(20190723FJ-B23)。

摘　　要：Epilepsy is a common neurological disorder characterized by recurrent seizures.Most anti epileptic drugs (AEDs)work by regulating the balance of the excitatory glutamatergic and inhibitory GABAergic transmission.However,the current AEDs cannot successfully control seizures in most (>70%) patients with temporal lobe epilepsy (TLE)[1],in whom seizures typically begin in the hippocampus.This may be caused by changes in the synaptic efficacy and remodeling of neural circuits,such as alterations in the distribution/expression of GABA_A receptor subunits and mossy-fiber sprouting.Since Dr.Karen Gale and colleagues originally described the seizure-modulating effects of nigral GABAergic transmission in the early 1980s [2]。

关 键 词：EPILEPSY alterations AEDS 

分 类 号：R742.1[医药卫生—神经病学与精神病学]