Glutamine metabolism in Th17/Treg cell fate:applications in Th17 cell-associated diseases  

作　　者：Guan Yang Yaoyao Xia Wenkai Ren 

机构地区：[1]Guangdong Laboratory of Lingnan Modern Agriculture,Guangdong Provincial Key Laboratory of Animal Nutrition Control,National Engineering Research Center for Breeding Swine Industry,College of Animal Science,South China Agricultural University,Guangzhou 510642,China [2]Department of Pathology,Microbiology and Immunology,Vanderbilt University School of Medicine,Nashville,TN 37232,USA

出　　处：《Science China(Life Sciences)》2021年第2期221-233,共13页中国科学（生命科学英文版）

基　　金：supported by the National Natural Science Foundation of China(31922079,31872365,and 31790411);Guangdong Basic and Applied Basic Research Foundation(2019B1515210002)。

摘　　要：Alteration in the Th17/Treg cell balance is implicated in various autoimmune diseases and these disease-associated pathologies.Increasing investigations have shown that glutamine metabolism regulates the differentiation of Th17 and Treg cells.Here we summarize the mechanisms by which glutamine metabolism regulates Th17/Treg cell fate.Some examples of a glutamine metabolism-dependent modulation of the development and progression of several Th17/Treg cell-associated diseases are provided afterward.This review will provide a comprehensive understanding of the importance of glutamine metabolism in the fate of Th17/Treg cell differentiation.

关 键 词：GLUTAMINE Th17 cells Treg cells MTOR UDP-GLCNAC 

分 类 号：Q939.91[生物学—微生物学]