非共同性斜视遗传学机制研究  

Study on Genetic Mechanism of Nonconcomitant Strabismus

作　　者：秦曼 胡敏[2] QIN Man;HU Min(Kunming Medical University,Kunming 650000,Yunnan,China;Affiliated Hospital of Yunnan University/the Second People’s Hospital of Yunnan Province,Kunming 650000,Yunnan,China)

机构地区：[1]昆明医科大学,云南昆明650000 [2]云南大学附属医院/云南省第二人民医院,云南昆明650000

出　　处：《医学信息》2021年第4期49-51,56,共4页Journal of Medical Information

基　　金：云南省科技厅——昆明医科大学应用基础研究联合专项面上项目〔编号:2019FE001(-095)〕;昆明医科大学研究生创新基金(编号:2020S227)。

摘　　要：斜视是指两眼不能同时注视目标,属眼外肌疾病,可分为共同性斜视和非共同性斜视两大类。非共同性斜视是指双眼出现眼位偏斜且同时伴有不同程度的眼球运动障碍的一类疾病。研究发现一些非共同性斜视表现出很强的家族性,先天性颅神经支配异常性疾病(CCDDS)和非共同性斜视紧密相关,并用来解释共同性斜视的遗传学机制,该病是由先天性颅神经核及其各自的颅神经发育异常引起的一组疾病,临床表现为相关肌肉运动或联动异常。本文就近年来对先天性颅神经支配异常性疾病的遗传学研究作一综述。Strabismus refers to the inability of both eyes to look at the target at the same time.It is an extraocular muscle disease and can be divided into two categories:concomitant strabismus and nonconcomitant strabismus.Nonconcomitant strabismus refers to a type of disease in which both eyes appear to be deviated and accompanied by varying degrees of eye movement disorders.Studies have found that some nonconcomitant strabismus show a strong familial nature,and congenital cranial nerve innervation abnormalities(CCDDS)are closely related to nonconcomitant strabismus,and used to explain the genetic mechanism of concomitant strabismus.The disease is a group of diseases caused by congenital cranial nerve nuclei and their respective cranial nerve development abnormalities.The clinical manifestation is abnormal muscle movement or linkage.This article reviews the genetic studies of congenital cranial nerve innervation disorders in recent years.

关 键 词：非共同性斜视 先天性颅神经支配异常性疾病 先天性眼外肌纤维化 DUANE眼球后退综合征 MOBIUS综合征 

分 类 号：R3[医药卫生—基础医学]