黏膜黑色素瘤原发部位与转移部位相关性分析  

Analysis of the correlation between the site of occurrence and the site of metastasis in mucosal melanoma

作　　者：向梅 梁宪斌[1] 赵东丽[1] 王艳[1] 胡姗姗[1] 张维真[1] XIANG Mei;LIANG Xianbin;ZHAO Dongli;WANG Yan;HU Shanshan;ZHANG Weizhen(The Third People's Hospital of Zhengzhou,Cancer Hospital Affiliated to Henan University,Henan Zhengzhou 450000,China)

机构地区：[1]郑州市第三人民医院,河南大学肿瘤医院,河南郑州450000

出　　处：《现代肿瘤医学》2021年第5期864-867,共4页Journal of Modern Oncology

基　　金：河南省医学科技攻关计划项目(编号:201602323)。

摘　　要：目的:探讨黏膜黑色素瘤的原发部位与转移部位的相关性及基因组学特征。方法:对经病理确诊为黏膜黑色素瘤的92例患者进行流行病学调查,对肿瘤原发部位及转移部位的相关因素进行总结分析。结果:头颈部为黏膜黑色素瘤高发部位46人(50%),其次为泌尿生殖系统25人(27.17%),肛管直肠21人(22.83%)。最常见转移部位均为区域淋巴结,头颈部、肛管直肠、泌尿生殖系统分别为63.04%、57.14%、32.00%;其次为肺转移,头颈部、肛管直肠、泌尿生殖系统分别为23.91%、19.05%、32.00%;肛管直肠和泌尿生殖系统来源黑色素瘤还易出现肝转移,分别为28.57%和20.00%。进行基因检测的33人中,BRAF V600E突变2例(6.06%),CKIT突变1例(3.03%),NRAS突变4例(12.12%)。结论:淋巴结转移最常见于头颈部黑色素瘤,其次为肛管直肠黑色素瘤,泌尿生殖系统来源黑色素瘤淋巴结转移比例较低;局部复发伴淋巴结转移在头颈部黑色素瘤约占1/3。基因检测及靶向治疗为更多患者带来生存获益。Objective:To investigate whether there is a correlation between the location of primary site and metastasis site of mucosal melanoma and the relationship between genomic characteristics and prognosis.Methods:Epidemiological investigation was carried out on 92 patients with mucous melanoma diagnosed by pathology,and the relevant factors of the primary and metastatic sites of the tumor were summarized and analyzed.Results:Among the 92 patients with mucosal melanoma,the head and neck had a high incidence of mucous melanoma,with a total of 46(50%),followed by the urogenital system in 25(27.17%) and anorectal in 21(22.83%).The most common metastatic sites of head and neck melanoma were regional lymph nodes(63.04%) and lung(23.91%).The most common metastatic sites of anorectal melanoma were regional lymph nodes(57.14%),lung(19.05%) and liver(28.57%).The most common metastatic sites of urogenital melanoma were regional lymph nodes(32.00%),lung(32.00%) and liver(20.00%).Among the 33 people who underwent genetic testing,there were 2(6.06%) had BRAF V600 E mutation,1(3.03%) had CKIT mutation,and 4(12.12%) had NRAS mutation.Conclusion:Lymph node metastasis is the most common in head and neck melanoma,followed by anorectal melanoma.The proportion of lymph node metastasis in urogenital melanoma is low.Local recurrence of head and neck is often accompanied by lymph node metastasis.Gene detection and targeted therapy bring survival benefits to more patients.

关 键 词：黏膜 黑色素瘤 原发部位 转移部位 基因检测 

分 类 号：R739.5[医药卫生—肿瘤]