口服制剂中苦味物质矫掩味的高分子材料概述  

Polymers Used as Flavor-masking Agents for Bitter Substances in Oral Administration Preparations

作　　者：许雅琪 叶军[1] 高越 高丽丽 刘玉玲[1] 杨艳芳 Xu Yaqi;Ye Jun;Gao Yue;Gao Lili;Liu Yuling;Yang Yanfang(Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China)

机构地区：[1]中国医学科学院北京协和医学院药物研究所,北京100050

出　　处：《中国药师》2021年第1期132-138,共7页China Pharmacist

基　　金：国家重大新药创制科技重大专项(编号:2018ZX09711001、2018ZX09721003);中国医学科学院医学与健康科技创新工程(编号:CIFMS-2019-I2M-1-005);北京协和医学院“中央高校基本科研业务费”项目(编号:3332019069)。

摘　　要：口服制剂中部分化学药物以及多种中药成分都具有苦味,极大限制了该类药物的应用。因此,减少药物苦味,提高患者依从性十分重要。近年来,高分子材料在掩盖药物不良味道中取得了一定成果。一些常用的高分子掩味材料如壳聚糖、环糊精和泊洛沙姆等可通过形成物理屏障、包合苦味分子或静电作用等加载苦味药物,减少药物与苦味受体的接触,以达到掩味的目的。本文将对目前常用的掩味高分子材料及其掩味机制进行综述。Most of chemical drugs and traditional Chinese medicines for oral administration are bitter,which limits their further applications in clinic. Therefore,it is very important to reduce the bitterness of drugs to improve patients’ compliance. In recent years,many polymers,such as chitosan,cyclodextrin,poloxamer and so on,have been widely used in taste masking for such bitter drugs.These polymers can reduce the contact between drugs and bitter taste receptors by forming a physical barrier,enclosing bitter molecules as well as loading bitter molecules through electrostatic interaction to play their roles in taste masking. This article reviewed the polymers used for taste masking,and their taste masking mechanisms were also summarized.

关 键 词：口服制剂 掩味 苦味药物 高分子材料 

分 类 号：R943[医药卫生—药剂学]