重症肌无力与运动  

Myasthenia Gravis and Exercise

作　　者：董蕊 张莹[1] DONG Rui;ZHANG Ying(The Second Affiliated Hospital of Harbin Medical University,Department of Neurology,Harbin 150086,China)

机构地区：[1]哈尔滨医科大学附属第二医院神经内科,哈尔滨150086

出　　处：《中国临床神经科学》2021年第1期116-120,共5页Chinese Journal of Clinical Neurosciences

摘　　要：重症肌无力(MG)是一种累及神经-肌肉接头突触后膜受体的自身免疫疾病,临床特征为波动性的肌肉无力。当MG患者病情不稳定时,会出现病理性疲劳导致运动减少,影响患者工作,甚至影响生活质量。全身型MG患者需要长期使用激素治疗,而药物的不良反应和运动减少,会增加代谢性、心血管等方面疾病的患病风险。随着MG治疗技术的进步,越来越多的患者病情得到良好控制,何时恢复运动、如何恢复,以提高患者的生活质量和重返工作岗位回归社会,已成为MG治疗的终极目标。与其他神经肌肉疾病比较,关于MG患者运动障碍的研究较少,目前缺少明确的治疗指南对MG患者的运动康复处方进行指导。文中对MG患者运动参与的试验和病例报告进行综述,为神经科和康复科医生制定MG患者运动处方提供参考。Myasthenia gravis(MG) is an autoimmune disease involving postsynaptic membrane receptors in neuromuscular junctions, which is characterized by fluctuating myasthenia gravis. When patients’ condition gets unstable, there will be pathological fatigue, resulting in reduced exercise, affecting the patient’s work, and even the quality of life;and generalized patients need long-term use of hormone therapy. The side effects of drugs and reduced exercise will increase the risk of metabolic, cardiovascular and other diseases. With the improvement of medical technology, more and more patients’ condition has been well controlled. When to resume exercise, how to recover, improving patients’ life quality, and returning to work and society have become the ultimate goals of the treatment. Compared with other neuromuscular diseases, there are few studies on exercise in patients with MG, and a lack of clear guidelines to guide the exercise prescription of patients with MG. The experiment and case reports of exercise participation in patients with MG were reviewed, which can be used as a reference for neurologists and rehabilitation doctors to formulate exercise prescriptions for MG patients.

关 键 词：重症肌无力 运动 有氧训练 无氧训练 呼吸训练 

分 类 号：R746.1[医药卫生—神经病学与精神病学]