双相障碍抑郁发作患者奖赏任务事件相关电位晚成分的特征  

Abnormal reward-related ERP late components in depressed patients with bipolar disorder

作　　者：王心羽 吴海燕 黄佳[1] 高晨阳[1] 唐晓晨 彭代辉[1] WANG Xinyu;WU Haiyan;HUANG Jia;GAO Chenyang;TANG Xiaochen;PENG Daihui(Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine(Shanghai Mental Health Center),Shanghai 200030,China)

机构地区：[1]上海交通大学医学院附属精神卫生中心(上海市精神卫生中心),上海200230

出　　处：《武汉大学学报（医学版）》2021年第2期312-316,共5页Medical Journal of Wuhan University

基　　金：上海市精神卫生中心临床研究中心项目(编号:CRC2018ZD05);上海市卫生健康委员会青年科学基金项目(编号:20174Y0223)。

摘　　要：目的:通过分析双相障碍抑郁发作患者在奖赏任务中事件相关电位(ERP)晚成分的特征,来探索双相抑郁对于奖赏反馈的脑电生理机制。方法:依据DSM-Ⅴ诊断标准纳入双相障碍抑郁发作患者24例,健康对照20例,采集64导脑电仪记录赌博范式实验过程的脑电信号。对被试接受输赢反馈后500~600 ms的波幅进行脑电时域分析,并进行组间差异统计。结果:两组间F3、Fz、F4电极点的波幅差异显著(P<0.05);在面对"损失"的实验范式对应的脑电成分中,患者组在F3、Fz电极点上的N500波幅更大、更深(P<0.05)。结论:经典赌博范式诱发了双相障碍患者对"损失"更强的N500负波,与双相抑郁对结果的情绪反应异常相关。Objective: To explore the characteristics of event-related potentials(ERP) late components in the reward task of patients in depressive episodes with bipolar disorder(BD).Methods: A randomized controlled clinical trial was used to enroll 24 BD depression patients and 20 healthy controls. Participants underwent the classical gambling paradigm while undergoing 64-channel electroencephalography. EEG data was segmented in epochs beginning 500-600 ms after win or loss feedbacks for timedomain analysis.Results: Variance analysis showed significantly difference in the amplitudes of F3,FZ, and F4 electrodes in the 500-600 ms time window. When facing loss, participants elicited larger and deeper N500 amplitudes at the F3 and Fz electrodes, which reached a significant level(P<0. 05).Conclusion: The classic gambling paradigm induced a deeper N500 after loss feedbacks in patients,which suggested an emotion dysregulation raised by negative outcomes.

关 键 词：双相障碍 抑郁发作 奖赏机制 事件相关电位 

分 类 号：R749.41[医药卫生—神经病学与精神病学]