代谢相关脂肪性肝病饮食干预新策略的研究进展  

Research advances in dietary intervention in the treatment of metabolic associated fatty liver disease

作　　者：叶俊钊 林衍松 钟碧慧[1] YE Junzhao;LIN Yansong;ZHONG Bihui(Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China)

机构地区：[1]中山大学附属第一医院消化内科,广州510080

出　　处：《临床肝胆病杂志》2021年第3期709-713,共5页Journal of Clinical Hepatology

基　　金：国家自然科学基金资助项目(81870404,81670518,81170392);广东省科技计划项目(2013B021800290,2014A020212118,2017A020215015)。

摘　　要：不良的饮食习惯是导致代谢相关脂肪性肝病(MAFLD)呈全球性流行的重要原因,而膳食模式调整更是MAFLD管理的基石。近年来大量新的治疗性膳食模式被提出并尝试应用于MAFLD的治疗,包括限制能量均衡饮食、低碳饮食、低血糖生成指数饮食、低游离糖饮食、轻断食饮食、高蛋白饮食、地中海饮食等,这些新方法在临床上应用的治疗效果不一。介绍了这些膳食治疗新策略的治疗理念、实践方法以及在国内外MAFLD人群治疗中的获益证据,为临床医生指导患者实现个体化的营养治疗提供新视角。Poor dietary habit is an important cause of the global prevalence of metabolic associated fatty liver disease(MAFLD),and the adjustment of dietary pattern is the cornerstone of MAFLD management.In recent years,a large number of new dietary intervention methods have been proposed and applied in the treatment of MAFLD,including calorie restrict diet,low-carbohydrate diet,low-glycemic index diet,low free sugar diet,intermittent fasting pattern,high protein diet,and Mediterranean diet,and these new methods have different effects in clinical practice.This article introduces the treatment concepts and practical methods of these new dietary treatment strategies and the evidence of their benefits in the treatment of MAFLD in China and globally,so as to provide a new perspective for clinicians to guide patients to achieve individualized nutritional therapy.

关 键 词：代谢相关脂肪性肝病 营养疗法 健康膳食 

分 类 号：R575.5[医药卫生—消化系统]