Mapping the Brain-Wide Cholinergic Neurons Projecting to Skeletal Muscle in Mice by High-Throughput Light Sheet Tomography  

作　　者：Dayu Chen Xiaofeng Cheng Xiong Yang Yongsheng Zhang Zhigang He Qian Wang Guojie Yao Xiuli Liu Shaoqun Zeng Jincao Chen Hongbing Xiang 

机构地区：[1]Department of Neurosurgery,Zhongnan Hospital of Wuhan University,Wuhan 430071,China [2]Department of Neurosurgery,Central Theater Command General Hospital of the People’s Liberation Army,Wuhan 430070,China [3]Britton Chance Center for Biomedical Photonics,Wuhan National Laboratory for Optoelectronics,Huazhong University of Science and Technology,Wuhan 430074,China [4]Ministry of Education Key Laboratory for Biomedical Photonics,School of Engineering Sciences,Huazhong University of Science and Technology,Wuhan 430074,China [5]Department of Emergency Medicine,Tongji Hospital of Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430074,China [6]Department of Anesthesiology and Pain Medicine,Tongji Hospital of Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China

出　　处：《Neuroscience Bulletin》2021年第2期267-270,共4页神经科学通报（英文版）

基　　金：This work was supported by grants from the Foundation of Health and Family Planning Commission of Hubei Province,China(WJ2018H0074);the National Natural Science Foundation of China(61721092,81670240 and 81873467).

摘　　要：Dear Editor,The cholinergic system plays an important role in regulating locomotion and motor functions by modulating neuronal activity[1].However,the anatomical relationships between the brain-wide cholinergic system and skeletal muscles remain unclear.To understand how this system modulates the activity of skeletal muscles,details of the pattern of cholinergic innervation and differences in the innervation of skeletal muscles are necessary.However,classical immunohistochemical methods are unable to test unequivocally whether a mapping exists in the connections from the brain to skeletal muscles.

关 键 词：SKELETAL muscles CHOLINERGIC 

分 类 号：R338[医药卫生—人体生理学]