结合多维度特征的病理图像病灶识别方法  

Lesion Recognition Method of Pathological Images Based on Multidimensional Features

作　　者：胡伟岸 邹俊忠[1] 郭玉成 张见[1] 王蓓[1] HU Wei’an;ZOU Junzhong;GUO Yucheng;ZHANG Jian;WANG Bei(School of Information Science and Engineering,East China University of Science and Technology,Shanghai 200237,China;Tsimage Medical Technology,Shenzhen,Guangdong 518083,China)

机构地区：[1]华东理工大学信息科学与工程学院,上海200237 [2]清影医疗科技(深圳)有限公司,广东深圳518083

出　　处：《计算机工程与应用》2021年第6期144-151,共8页Computer Engineering and Applications

基　　金：国家自然科学基金(61773164);上海市自然科学基金(16ZR1407500)。

摘　　要：长时间的病理图像人工诊断会使医生产生视觉疲劳,误诊和漏诊情况容易发生。针对以上现象,提出一种结合卷积神经网络中多维度特征的方法,快速准确识别出病理图像中的病灶区域。使用感兴趣区提取及图像裁剪获得小尺寸图块数据;使用染色校正的方法以解决图块染色不均,对比度弱等问题;搭建深度学习模型,使用多组深度可分离卷积提取不同尺度的特征,加入残差连接以避免梯度消失,联合不同维度的特征信息以提高特征利用率。实验结果表明,染色校正能够提高预测准确率,上述模型具有参数少、鲁棒性强的特点,最终对病理图像病灶的识别均能达到较高的准确率,假阳性及假阴性均较低,未来将具有广泛的应用前景。Time-consuming artificial diagnosis of pathological images will cause visual fatigue of doctors,while both misdiagnosis and missed diagnosis are easy to occur.In response to the above phenomena,a method combining multidimensional features of convolutional neural network is proposed to quickly and accurately identify lesion in pathological images.ROI extraction and image cutting is used to obtain small-scale block data.The method of stain correction is used to solve the problems of uneven staining and weak contrast in block data.A deep learning model is built,using several depthwise separable convolution to extract features of different dimensions,adding residual connection to avoid gradient disappearance,combining the feature information of different dimensions to improve feature utilization.The experimental results show that stain correction can improve prediction accuracy and the above model has the characteristics of few parameters and strong robustness.At the same time,the accuracy of lesion recognition in pathological images can reach a high level,while both false positive rate and false negative rate are low,so it will have a broad application prospect in the future.

关 键 词：多维度 深度学习 卷积神经网络 深度可分离 染色校正 病理图像 病灶 

分 类 号：TP391[自动化与计算机技术—计算机应用技术]