Radiation-induced oral mucositis hamster model using a linear accelerator enhances clinical relevance of preclinical studies for treatment strategy investigation  

作　　者：Carolyn T.Jordan Emily M.Bradford Dennis C.Cheek Mahesh Kudrimoti Craig S.Miller Molly H.Smith J.Zach Hilt Thomas D.Dziubla 

机构地区：[1]Department of Chemical and Materials Engineering,University of Kentucky,Lexington,KY,USA [2]Department of Internal Medicine,University of Kentucky,Lexington,KY,USA [3]Department of Radiation Medicine,University of Kentucky,Lexington,KY,USA [4]Department of Oral Health Practice,University of Kentucky,Lexington,KY,USA [5]Department of Oral and Maxillofacial Pathology,University of Kentucky,Lexington,KY,USA

出　　处：《Animal Models and Experimental Medicine》2021年第1期47-53,共7页动物模型与实验医学（英文）

基　　金：National Institute of Dental and Craniofacial Research,Grant/Award Number:R44DE023523。

摘　　要：Translational animal models for oral mucositis(OM)are necessary to simulate and assess the bioclinical effects and response in humans.These models should simulate high levels of radiation exposure that leads to oxidative stress and inflammatoryinitiated tissue changes.Hamster models have been extensively studied to observe pathological effects of radiation exposure and help in the development of effective treatments.To successfully evaluate the potential for treatment regimens with consistency and relevance,a radiation-induced OM hamster model was developed using a clinical linear accelerator utilized by cancer patients daily.The dose exposure to the isolated,everted cheek pouch of a hamster,as well as the progression of injury,proinflammatory marker,histological,and elasticity analyses of the buccal pouch were conducted to verify replicability and reproducibility of the injury model.The findings from this model demonstrated its ability to consistently induce injury and resolution over 28 days using an acute dose of 60 Gy.This model was developed to enhance clinical relevance when evaluating potential efficacious treatments and can now be utilized in efficacy studies to better evaluate developed therapeutics in a preclinical model that is easy to translate to clinical studies..

关 键 词：animal models RADIOTHERAPY STOMATITIS 

分 类 号：R781.5[医药卫生—口腔医学]