Use of granulocyte/monocytapheresis in ulcerative colitis:A practical review from a European perspective  

作　　者：Eugeni Domènech Joan-Ramon Grífols Ayesha Akbar Axel U Dignass 

机构地区：[1]Department of Gastroenterology,Hospital Universitari Germans Trias i Pujol,Badalona 08916,Catalonia,Spain [2]Department of Medicine,Universitat Autònoma de Barcelona,Badalona 08916,Catalonia,Spain [3]Centro de Investigaciones Biomédicas en Red de Enfermedades Hepáticas y Digestivas(CIBEREHD),Badalona 08916,Catalonia,Spain [4]Blood and Tissue Bank,Hospital Universitari Germans Trias i Pujol,Badalona 08916,Catalonia,Spain [5]IBD Unit,St.Mark’s Hospital and Academic Institute,London HA13UJ,United Kingdom [6]Department of Medicine I,Agaplesion Markus Hospital,Goethe-University,Frankfurt am Main 60431,Germany

出　　处：《World Journal of Gastroenterology》2021年第10期908-918,共11页世界胃肠病学杂志（英文版）

摘　　要：Half of the patients with ulcerative colitis require at least one course of systemic corticosteroids in their lifetime.Approximately 75%of these patients will also require immunosuppressive drugs(i.e.,thiopurines or biological agents)in the mid-term to avoid colectomy.Immunosuppressive drugs raise some concerns due to an increased risk of serious and opportunistic infections and cancer,particularly in elderly and co-morbid patients,underlining the unmet need for safer alternative therapies.Granulocyte/monocytapheresis(GMA),a CE-marked,non-pharmacological procedure for the treatment of ulcerative colitis(among other immune-mediated diseases),remains the only therapy targeting neutrophils,the hallmark of pathology in ulcerative colitis.GMA has proven its efficacy in different clinical scenarios and shows an excellent and unique safety profile.In spite of being a first line therapy in Japan,GMA use is still limited to a small number of centres and countries in Europe.In this article,we aim to give an overview from a European perspective of the mechanism of action,recent clinical data on efficacy and practical aspects for the use of GMA in ulcerative colitis.

关 键 词：GRANULOCYTE MONOCYTE Ulcerative colitis Inflammatory bowel disease APHERESIS Safety 

分 类 号：R574.62[医药卫生—消化系统]