Neuropeptide Y receptors:a promising target for cancer imaging and therapy 5th China-Europe Symposium on Biomaterials in Regenerative Medicine(CESB 2015)Hangzhou,China April 7–10,2015  

作　　者：Juan Li Yuchen Tian Aiguo Wu 

机构地区：[1]Key Laboratory of Magnetic Materials and Devices&Division of Functional Materials and Nano Devices,Ningbo Institute of Materials Technology&Engineering,Chinese Academy of Sciences,Ningbo 315201,China

出　　处：《Regenerative Biomaterials》2015年第3期215-219,共5页再生生物材料（英文版）

基　　金：This work was supported by the Natural Science Foundation of China(Grant No.51303196 and U1432114);Ningbo Natural Science Foundation of China(Grant No.2013A610092);the Key Breakthrough Program of the Chinese Academy of Sciences(KGZD-EW-T06);Hundred Talents Program of Chinese Academy of Sciences(A.G.U.,2010-735).

摘　　要：Neuropeptide Y(NPY)was first identified from porcine brain in 1982,and plays its biological functions in humans through NPY receptors(Y1,Y2,Y4 and Y5).NPY receptors are known to mediate various physiological functions and involve in a majority of human diseases,such as obesity,hypertension,epilepsy and metabolic disorders.Recently,NPY receptors have been found to be overexpressed in many cancers,so they emerged as promising target in cancer diagnosis and therapy.This review focuses on the latest research about NPY and NPY receptors,and summarizes the current knowledge on NPY receptors expression in cancers,selective ligands for NPY receptors and their application in cancer imaging and therapy.

关 键 词：neuropeptide Y receptors CANCERS imaging therapy 

分 类 号：R74[医药卫生—神经病学与精神病学]