Mitochondrial replacement in macaque monkey offspring by first polar body transfer  

作　　者：Zhanyang Wang Yuzhuo Li Xianfa Yang Yan Wang Yanhong Nie Yuting Xu Xiaotong Zhang Yong Lu Tikui Zhang Qiming Liu Naihe Jing Zhen Liu Qiang Sun 

机构地区：[1]Institute of Neuroscience,State Key Laboratory of Neuroscience,CAS Key Laboratory of Primate Neurobiology,CAS Center for Excellence in Brain Science and Intelligence Technology,Chinese Academy of Sciences,Shanghai 200031,China [2]Zhongshan Hospital,State Key Laboratory of Genetic Engineering,Institutes of Biomedical Sciences,Fudon University,Shanghai 200032,China [3]Shonghoi Institute of Biochemistry and Cell Biology,Center for Excellence in Molecular Cell Science,Chinese Academy of Sciences,Shanghai 200031,Chino

出　　处：《Cell Research》2021年第2期233-236,共4页细胞研究（英文版）

基　　金：the National Key R&D Program of China(2018YFC1003000 to Q.S.and Z.L.);the National Natural Science Foundation of China(31825018 to Q.S.);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB32060100 to Q.S.);the Shanghai Municipal Science and Technology Major Project(2018SHZDZX05 to Q.S.);the Shanghai Municipal Government Bureau of Science and Technology(18JC1410100 to Q.S.);Shanghai Young Talents Sailing Program(18YF1427500 to Z.L.).

摘　　要：Dear Editor,Mitochondrial DNA(mtDNA)mutations are materally inherited to the offspring and mitochondrial replacement therapy(MRT)provides.a promising approach for preventing mtDNA-related 1,2 diseases.First polar body transfer(PB1T)has been used for mitochondrial replacement to generate mouse offspring and normal human embryos that yield embryonic stem cells.However,generation of primate offspring using PB1T has not been reported.Here,we show that PB1T-based mitochondrial replacement could generate healthy macaque monkey(Macaca fascicularis),a useful non-human primate model for evaluating methods that may improve the efficiency and safety of PB1T for MRT.

关 键 词：MITOCHONDRIAL OFFSPRING REPLACEMENT 

分 类 号：Q2[生物学—细胞生物学]