The effects of borneol on the pharmacokinetics and brain distribution of tanshinone IIA,salvianolic acid B and ginsenoside Rg1 in Fufang Danshen preparation in rats  

作　　者：ZHANG Jie LIU Sheng-Lan WANG Hui SHI Li-Ying LI Jin-Ping JIA Lu-Juan XIE Bao-Ping 

机构地区：[1]The Third Xiangya hospital,Central South University,Changsha 410013,China [2]The Fourth Hospital of Changsha,Changsha 410013,China [3]The Central Hospital of Taian,Taian 271000,China [4]Xiangya School of Pharmaceutical Sciences,Central South University,Changsha 410013,China [5]Gannan Medical University,Gannan,341000,China

出　　处：《Chinese Journal of Natural Medicines》2021年第2期153-160,共8页中国天然药物（英文版）

基　　金：the Natural Science Foundation of Hunan Province(Nos.2017JJ2338 and 2020JJ4860);the National Key Specialty Construction Project of Clinical Pharmacy(No.2013-5).

摘　　要：Fufang Danshen preparation(FDP)is consisted of Salviae Miltiorrhizar Radix et Rhizoma(Danshen),Notoginseng Radix et Rhizoma(Sanqi)and Borneolum Syntheticum(borneol).FDP is usually used to treat myocardial ischemia hypoxia,cerebral ischemia and alzheimer’s disease,etc.In the treatment of cerebrovascular diseases,borneol is usually used to promote the absorption and distribution of the bioactive components to proper organs,especially to the brain.The purpose of this study is investigating the effects of borneol on the pharmacokinetics and brain distribution of tanshinone IIA(TS IIA),salvianolic acid B(SAB)and ginsenoside Rg1 in FDP.Male healthy Sprague-Dawley(SD)rats were given Danshen extracts,Sanqi extracts(Panax notoginseng saponins)or simultaneously administered Danshen extracts,Sanqi extracts and borneol.Plasma and brain samples were collected at different points in time.The concentration of TS IIA,SAB and Rg1 was determined by UPLC-MS/MS method.The main pharmacokinetics parameters of plasma and brain tissue were calculated by using Phoenix WinNolin 6.1 software.In comparison with Danshen and Sanqi alone,there were significant differences in pharmacokinetic parameters of TS IIA,SAB and Rg1,and the brain distribution of SAB and TS IIA when Danshen,Sanqi and borneol were administrated together.Borneol statistically significant shortened tmax of TS IIA,SAB and Rg1 in plasma and brain,increased the bioavaiability of Rg1,inhibited metabolism of Rg1 and enhanced the transport of TS IIA and SAB to brain.These results indicated that borneol could affect the multiple targets components and produce synergistic effects.Through accelerating the intestinal absorption and brain distribution,borneol caused the effective ingredients of Danshen and Sanqi to play a quicker therapeutic role and improved the therapeutic effect.

关 键 词：BORNEOL Fufang Danshen preparation Tanshinone IIA Salvianolic acid B Ginsenoside Rg1 PHARMACOKINETICS 

分 类 号：R969[医药卫生—药理学]