急性髓细胞白血病免疫表型伴淋系表达与染色体核型异常的关系  

Relationship between abnormal expression of immunophenotypes in acute myeloid leukemia and karyotypic abnormalities

作　　者：孙幸[1] 王红[1] 吴蔚[1] 倪军[1] 方悦之[1] 沈连军[1] 施青青[1] 吉薇[1] 顾健[1] SUN Xing;WANG Hong;WU Wei;NI Jun;FANG Yuezhi;SHEN Lianjun;SHI Qingqing;JI Wei;GU Jian(Northern Jiangsu People's Hospital,Yangzhou Institute of Hematology,Yangzhou,225001,China)

机构地区：[1]江苏省苏北人民医院扬州市血液学研究所,江苏扬州225001

出　　处：《临床血液学杂志》2021年第1期52-55,共4页Journal of Clinical Hematology

基　　金：院级课题项目(No:yzucms201630)。

摘　　要：目的:探讨急性髓细胞白血病(AML)免疫表型伴系表达与染色体核型异常的相关性。方法:选择2017年1月—2019年6月我院血液科初诊AML患者共131例,男69例,女62例,平均年龄58岁(年龄分布22~88岁),其中包括M1 6例,M2 68例,M3 15例,M4 30例,M5 10例,M6 1例,急性混合细胞白血病1例。结果:131例患者中伴系表达62例,其中伴淋系异常表达,依次为伴CD56+31例,CD7+15例,CD19+10例,CD2+、CD5+各1例,其中两种以上伴系表达19例。131例患者中有31例未见染色体核型异常分裂相改变,未列入统计,15例M3患者由于免疫分型及染色体的特殊性,也不列入统计,最终入组85例。采用χ2检验统计分析发现,染色体异常患者更容易出现伴系表达,差异有统计学意义(χ^(2)=3.994,P=0.045 7)。结论:AML免疫表型伴淋系异常表达主要为CD56、CD7、CD19等,存在伴系表达的患者更容易出现染色体异常。CD56可能是重现性染色体异常出现的重要提示指标。Objective: To investigate the relationship between the expression of immunophenotypes in acute myeloid leukemia(AML) and karyotypic abnormalities. Methods: We selected a total of 131 patients with AML in our department of Hematology from January 2017 to June 2019. There were 69 males and 62 females with an average age of 58 years(age distribution 22 to 88 years), including 6 cases of M1, 68 cases of M2, 15 cases of M3, 30 cases of M4, 10 cases of M5, 1 case of M6, and 1 case of acute mixed cell leukemia. Results: Among the 131 patients, 62 cases were associated with mistranslation expressed, which abnormal expression were accompanied with 31 cases of CD56+, 15 cases of CD7+, 10 cases of CD19+, 1 case of CD2+, 1 case of CD5+, and 19 cases of two or more concomitant lines. In this group 31 patients had no abnormal mitotic phase changes, which were not included in the statistics. Fifteen patients with M3 were not counted because of their immunophenotyping and chromosome specificity. Finally, 85 patients were enrolled. Statistical analysis of chi-square test showed that the patients with chromosomal abnormalities were more likely to be associated with the expression, and the difference was statistically significant(χ^(2)=3.994, P=0.045 7). Conclusion: The abnormal expression of immunophenotypes in AML mainly includes CD56, CD7, CD19, etc. Patients with abnormal expression are more likely to have chromosomal abnormalities. CD56+may be a very important indicator of recurrent chromosomal abnormalities.

关 键 词：急性髓细胞白血病 伴系表达 染色体异常 

分 类 号：R733.71[医药卫生—肿瘤]