Elevated L-lactate Promotes Major Cellular Pathologies Associated with Neurodegenerative Diseases  

作　　者：Andrew DChapp Jessica EBehnke Kyle MDriscoll Taija Hahka Zoe LaLonde Zhiying Shan Qing-Hui Chen 

机构地区：[1]Department of Kinesiology and Integrative Physiology,Michigan Technological University,Houghton,MI 49931,USA [2]Department of Biological Sciences,Michigan Technological University,Houghton,MI 49931,USA

出　　处：《Neuroscience Bulletin》2021年第3期380-384,共5页神经科学通报（英文版）

摘　　要：Dear Editor,Small,short-chain fatty acids(SCFAs)(acetic acid,propionic acid,and butyric acid:conjugate bases,acetate,propionate,and butyrate)as well as the alpha-hydroxy acid,L-lactic acid(conjugate base,L-lactate)are important energy substrates and signaling molecules in the central nervous system(CNS)[1,2].L-lactic acid is produced by glycolysis[3]and gut microbes[4]and is released in large quantities during exercise[5].

关 键 词：CONJUGATE BASES QUANTITIES 

分 类 号：R741.02[医药卫生—神经病学与精神病学]