乙型肝炎病毒诱发肝细胞癌分子机制研究进展  

Advances on molecular mechanism of hepatitis B virusinduced hepatocellular carcinoma

作　　者：邵一鸣 苏力德 郝睿 王茜茜 那仁满都拉 SHAO Yiming;SU Lide;HAO Rui;WANG Qianqian;NARANMANDURA Hua(College of Pharmaceutical Sciences,Inner Mongolia Medical University,Hohhot 010000,China;School of Medicine,Zhejiang University,Hangzhou 310058,China)

机构地区：[1]内蒙古医科大学药学院,内蒙古呼和浩特010000 [2]浙江大学医学院,浙江杭州310058

出　　处：《浙江大学学报（医学版）》2021年第1期113-122,共10页Journal of Zhejiang University(Medical Sciences)

基　　金：国家自然科学基金(82003875,81872942);浙江省卫生高层次创新人才培养工程[浙卫发(2018)62号];浙江省博士后择优资助项目(ZJ2020154)。

摘　　要：乙型肝炎病毒(HBV)诱导肝细胞癌(HCC)的发生是一个多阶段、多因素相互作用的复杂过程。HBV促进HCC发生、发展的途径主要包括HBV DNA整合至宿主肝细胞基因组从而影响整合位点的基因功能、形成致癌作用的截短蛋白、造成宿主基因组的不稳定,HBV基因组S、C、X区基因突变,HBV X基因编码的HBx蛋白激活原癌基因、抑制抑癌基因等。本文综述了近年来HBV诱发HCC分子机制的研究进展,以期为HCC预防、早期预测及术后辅助治疗提供理论指导。The pathogenesis of hepatitis B virus(HBV)-associated hepatocellular carcinoma(HCC)is complicated with the crosstalk of multiple factors and the multi-step processes.The main mechanisms underlying the HBV-induced HCC include:①integration of HBV DNA into the host hepatocyte genome to alter gene function at the insertion site,resulting in host genome instability and expression of carcinogenic truncated proteins;②HBV gene mutations at S,C,and X coding regions in the genome;③HBV X gene-encoded HBx protein activates proto-oncogenes and inhibits tumor suppressor genes,leading to the HCC occurrence.In this article,the recent research progress on the molecular mechanism of HBV-induced HCC is comprehensively reviewed,so as to provide insights into the prevention,early prediction and postoperative adjuvant therapy of HCC.

关 键 词：乙型肝炎病毒 肝细胞癌 基因突变 基因整合 乙型肝炎病毒X蛋白 综述 

分 类 号：R735.7[医药卫生—肿瘤]