Neuroglobin and neuroprotection:the role of natural and synthetic compounds in neuroglobin pharmacological induction  

作　　者：Lidia Ciccone Susanna Nencetti Simone Socci Elisabetta Orlandini 

机构地区：[1]Department of Pharmacy,University of Pisa,Pisa,Italy [2]Department of Earth Sciences,University of Pisa,Pisa,Italy [3]Research Center“E.Piaggio,”University of Pisa,Pisa,Italy

出　　处：《Neural Regeneration Research》2021年第12期2353-2358,共6页中国神经再生研究（英文版）

基　　金：This work was supported by the Italian Ministero dell’Istruzione,dell’Universitáe della Ricerca PRIN 2017SNRXH3(to EO and SN);PRA_2018_20 University of Pisa(to EO).

摘　　要：Neuroglobin(Ngb)is a 17 kDa monomeric hexa-coordinated heme protein belonging to the globin family.Ngb is mainly expressed in neurons of the central and peripheral nervous system,although moderate levels of Ngb have been detected in non-nervous tissues.In the past decade,Ngb has been studied for its neuroprotective role in a large number of neurological disorders such as Alzheimer’s disease,Huntington’s disease,brain ischemia and hypoxia.This review discusses and summarizes the natural compounds and the small synthetic molecules capable of modulating Ngb expression that exhibits a protective role against various neurodegenerative diseases.

关 键 词：NEUROGLOBIN neuroglobin pharmacological induction NEUROPROTECTION neurodegenerative diseases natural compounds synthetic small molecules Alzheimer’s disease Huntington’s disease 

分 类 号：R96[医药卫生—药理学]