Exercise intervention under hypoxic condition as a new therapeutic paradigm for type 2 diabetes mellitus:A narrative review  

作　　者：Sung-Woo Kim Won-Sang Jung Sochung Chung Hun-Young Park 

机构地区：[1]Physical Activity and Performance Institute(PAPI),Konkuk University,Seoul 05029,South Korea [2]Department of Pediatrics,Konkuk University Medical Center,Research Institute of Medical Science,Konkuk University,School of Medicine,Seoul 05029,South Korea [3]Department of Sports Science and Medicine,Konkuk University,Seoul 05029,South Korea

出　　处：《World Journal of Diabetes》2021年第4期331-343,共13页世界糖尿病杂志（英文版）（电子版）

基　　金：Supported by Ministry of Education of the Republic of Korea;the National Research Foundation of Korea,No. NRF-2019S1A5A2A03034583。

摘　　要：This review aims to summarize the health benefits of exposure to hypoxic conditions during exercise in patients with type 2 diabetes mellitus(T2 DM).Exposure to hypoxic conditions during exercise training positively changes the physiological response in healthy subjects.Exposure to hypoxic conditions during exercise could markedly increase skeletal muscle glucose uptake compared to that in normoxic conditions.Furthermore,post-exercise insulin sensitivity of T2 DM patients increases more when exercising under hypoxic than under normoxic conditions.Regular exercise under short-term hypoxic conditions can improve blood glucose control at lower workloads than in normoxic conditions.Additionally,exercise training under short-term hypoxic conditions can maximize weight loss in overweight and obese patients.Previous studies on healthy subjects have reported that regular exercise under hypoxic conditions had a more positive effect on vascular health than exercising under normoxic conditions.However,currently,evidence indicating that exposure to hypoxic conditions could positively affect T2 DM patients in the long-term is lacking.Therefore,further evaluations of the beneficial effects of exercise under hypoxic conditions on the human body,considering different cycle lengths,duration of exposures,sessions per day,and the number of days,are necessary.In this review,we conclude that there is evidence that exercise under hypoxic conditions can yield health benefits,which is potentially valuable in terms of clinical care as a new intervention for T2 DM patients.

关 键 词：EXERCISE HYPOXIA INSULIN-RESISTANCE Metabolism Type 2 diabetes mellitus Weight loss 

分 类 号：R587.1[医药卫生—内分泌]