Primary bone anaplastic lymphoma kinase positive anaplastic largecell lymphoma: A case report and review of the literature  

作　　者：Wei Zheng Qiao-Qiao Yin Tian-Chen Hui Wen-Hao Wu Qing-Qing Wu Hai-Jun Huang Mei-Juan Chen Rong Yan Yi-Cheng Huang Hong-Ying Pan 

机构地区：[1]Department of Infectious Diseases,Zhejiang Provincial People’s Hospital People’s Hospital of Hangzhou Medical College,Hangzhou 310014,Zhejiang Province,China [2]The Graduate School,Bengbu Medical College,Bengbu 233030,Anhui Province,China [3]The Graduate School,Qingdao University,Qingdao 266071,Shandong Province,China [4]The Second School of Clinical Medicine,Zhejiang Chinese Medicinal University,Hangzhou 310053,Zhejiang Province,China

出　　处：《World Journal of Clinical Cases》2021年第14期3403-3410,共8页世界临床病例杂志

基　　金：Supported by National Science and Technology Major Subproject of China,No.2018ZX10302205-002;Chinese Foundation for Hepatitis Prevention and Control-Tianqing Liver Disease Research Fund Subject,No.TQGB2020168.

摘　　要：BACKGROUND Primary bone lymphoma(PBL)is an uncommon extranodal disease that represents approximately 1%-3%of lymphomas.Anaplastic lymphoma kinase(ALK)positive anaplastic large-cell lymphoma(ALCL)is an extremely rare type of PBL.The aim of this report is describe the symptoms,diagnosis,and treatment of primary bone ALK-positive ALCL.CASE SUMMARY A 66-year-old man presented to our hospital with neck and shoulder pain and intermittent fever that lasted for 1 mo.After extensive evaluation,positron emission tomography-computed tomography(CT)examination showed multiple osteolytic bone lesions without other sites lesions.CT-guided biopsy of the T10 vertebral body was performed,and the pathology results showed that neoplastic cells were positive for ALK-1,CD30,and CD3.A diagnosis of primary bone ALK positive ALCL was ultimately made.The patient was in partial response after four cycle soft cyclophosphamide,doxorubicin,vincristine,and prednisone chemotherapy,and we planned to repeat the biopsy and radiological examination after completion of the fifth cycle of therapy.CONCLUSION Primary bone ALK positive ALCL is a rare disease and physicians should keep in mind that ALCL can present with isolated osseous involvement without nodal involvement,and lymphoma should be considered in the differential diagnosis of primary bone lesions.

关 键 词：Anaplastic large cell lymphoma Anaplastic lymphoma kinase Primary bone lymphoma Bone involvement OSTEOLYSIS Case report 

分 类 号：R738.1[医药卫生—肿瘤]