黄酒多糖对炎症性肠病及便秘作用机制的研究进展  

Research progress on the mechanism of Huangjiu polysaccharides on inflammatory bowel disease and constipation

作　　者：史瑛 冯欣静[1,2] 周志磊 姬中伟 徐岳正[3] 毛健 SHI Ying;FENG Xinjing;ZHOU Zhilei;JI Zhongwei;XU Yuezheng;MAO Jian(National Engineering Laboratory for Cereal Fermentation Technology,Jiangnan University,Wuxi 214122,China;School of Food Science and Technology,Jiangnan University,Wuxi 214122,China;National Engineering Research Center of Chinese Rice Wine,Shaoxing 312000,China)

机构地区：[1]粮食发酵工艺与技术国家工程实验室(江南大学),江苏无锡214122 [2]江南大学食品学院,江苏无锡214122 [3]国家黄酒工程技术研究中心,浙江绍兴312000

出　　处：《食品与发酵工业》2021年第9期275-283,共9页Food and Fermentation Industries

基　　金：国家重点研发计划项目(2018YFD0400401);国家自然科学基金项目(32001710);国家轻工技术与工程一流学科自主命题(LITE2018-13);中国博士后科学基金站前特别资助项目(2019TQ0122),江苏省自然科学基金青年基金项目(BK20200600)。

摘　　要：独特的酿造体系及低温长时的酿造工艺赋予了黄酒丰富的生物活性物质,多糖作为黄酒中主要的生物活性成分,含量丰富,种类独特,具有平衡肠道菌群、改善肠内环境等功效。由于黄酒多糖组分复杂,难以提取专一成分进行靶向研究,目前针对黄酒多糖的功能研究主要集中于调节肠道菌群,对其他肠道疾病的影响及其作用机制尚未明确。该文论述了黄酒多糖的来源、提取工艺、结构分析,并阐述了黄酒多糖等膳食多糖对机体肠道屏障的维护、便秘症状的缓解及炎症性肠病的治疗机理,为黄酒多糖的后续功能研究提供了理论基础与新的思路。As one of the national wines in China,Huangjiu(Chinese rice wine)has a brewing history of thousands of years.The abundant bioactive compounds in Huangjiu are processed during low-temperature and long-term brewing under the unique multi-species involved fermentation system.Polysaccharides are essential bioactive components in Huangjiu,which have effects in restoration of gut microbiota and improvement of intestinal ecology.It is relatively difficult to extract specific polysaccharide components for targeted research due to the complex components in Huangjiu polysaccharides.Recent studies mainly focused on the function of Huangjiu polysaccharides in regulation of gut microbiota,while the effects and mechanisms of Huangjiu polysaccharides on intestinal diseases remain unknown.This review summarizes the original source,extraction methods and the structural analysis of Huangjiu polysaccharides,as well as the mechanisms of dietary polysaccharides including Huangjiu polysaccharides on the maintenance of intestinal barrier,alleviation of constipation symptoms and treatment of inflammatory bowel disease.The review is expected to provide theoretical basis and new insights for study on the function of Huangjiu polysaccharides.

关 键 词：黄酒多糖 肠道菌群 肠道屏障 便秘 炎症性肠病 

分 类 号：TS262.4[轻工技术与工程—发酵工程]