Design and structural characterization of autoinhibition-compromised full-length Ran  

作　　者：Yuping Tan Yuqing Zhang Qiao Zhou Da Jia Qingxiang Sun 

机构地区：[1]Department of Pathology,State Key Laboratory of Biotherapy and Cancer Centre,West China Hospital,Sichuan University and Collaborative Innovation Centre of Biotherapy,Chengdu 610041,China [2]Key Laboratory of Birth Defects and Related Diseases of Women and Children,Department of Paediatrics,Division of Neurology,West China Second University Hospital,Sichuan University,Chengdu 610041,China

出　　处：《Signal Transduction and Targeted Therapy》2021年第3期574-576,共3页信号转导与靶向治疗（英文）

基　　金：supported by the National Natural Science Foundation of China(#80502629).

摘　　要：Dear Editor,The Ras-related nuclear protein Ran is a small GTPase that functions in nuclear transport,mitotic spindle formation,nuclear-envelope/nudear-pore complex assembly,and other diverse cytoplasmic activities.1,2 Unlike other Ras superfamily proteins,Ran contains a unique autoinhibitory C-terminal tail(C-tail)that accounts for an estimated tenfold lower affinity for GTP as compared with GDP.Multiple missense cancer mutations at the C-tail have been observed,but the biological significance is unknown.

关 键 词：NUDE structural characterization 

分 类 号：R730[医药卫生—肿瘤]