Intercellular mitochondrial transfer as a means of tissue revitalization  

作　　者：Delin Liu Youshui Gao Jiao Liu Yigang Huang Junhui Yin Yuyao Feng Linjing Shi Bruno PMeloni Changqing Zhang Minghao Zheng Junjie Gao 

机构地区：[1]Centre for Orthopaedic Research,School of Surgery,The University of Western Australia,Nedlands,WA 6009,Australia [2]Perron Institute for Neurological and Translational Science,Nedlands,WA 6009,Australia [3]Department of Orthopaedics,Shanghai Jiao Tong University Affiliated Shanghai Sixth People's Hospital,Shanghai 200233,China [4]Department of Hepatobiliary Surgery,Shanghai Public Health Clinical Center,Fudan University,Shanghai 200083,China [5]School of Medicine,Zhejiang University,Hangzhou,Zhejiang Province 310058,China [6]School of Life Sciences,Zhejiang University,Hangzhou,Zhejiang Province 310058,China

出　　处：《Signal Transduction and Targeted Therapy》2021年第3期705-722,共18页信号转导与靶向治疗（英文）

基　　金：supported by the grants from National Natural Science Foundation of China(Nos.81820108020 and 81672143);Shanghai Pujiang Program(No.2020PJD039);the fund from China Scholarship Council.

摘　　要：As the crucial powerhouse for cell metabolism and tissue survival,the mitochondrion frequently undergoes morphological or positional changes when responding to various stresses and energy demands.In addition to intracellular changes,mitochondria can also be transferred intercellularly.Besides restoring stressed cells and damaged tissues due to mitochondrial dysfunction,the intercellular mitochondrial transfer also occurs under physiological conditions.In this review,the phenomenon of mitochondrial transfer is described according to its function under both physiological and pathological conditions,including tissue homeostasis,damaged tissue repair,tumor progression,and immunoregulation.Then,the mechanisms that contribute to this process are summarized,such as the trigger factors and transfer routes.Furthermore,various perspectives are explored to better understand the mysteries of cell-cell mitochondrial trafficking.In addition,potential therapeutic strategies for mitochondria-targeted application to rescue tissue damage and degeneration,as well as the inhibition of tumor progression,are discussed.

关 键 词：METABOLISM HOMEOSTASIS DEGENERATION 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]