食管鳞癌动物模型研究进展  

Research progress of animal models of esophageal squamous cell carcinoma

作　　者：张鑫平 宋帅[1] 常栋[1] Zhang Xinping;Song Shuai;Chang Dong(Department of Thoracic Surgery,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China)

机构地区：[1]首都医科大学附属北京友谊医院胸外科,100050

出　　处：《国际外科学杂志》2021年第4期279-283,共5页International Journal of Surgery

基　　金：吴阶平医学基金会-临床科研专项资助(320.6750.18475)。

摘　　要：食管癌是常见的消化道恶性肿瘤之一,其确切的病因及发病机制尚未完全明确。食管癌动物模型的建立,为食管癌的基础和临床前研究提供支持,对于进一步研究明确发病机制及和探索研发新的治疗药物具有重要意义。目前研究常用的食管鳞癌动物模型主要有化学诱导模型、异位移植模型和原位移植模型,随着人源性肿瘤动物研究的不断进展,移植瘤模型也得到越来越广泛地应用。无论哪种模型都各有其优缺点及适用性,应根据实验目的合理选择。本文综合近年来有关食管鳞癌动物模型的研究进展,探讨目前科研及临床前常用模型,为食管癌临床治疗提供理论参考。Esophageal cancer is one of the common malignancies of the digestive tract,and its exact etiology and pathogenesis have not been completely clear.The establishment of animal model of esophageal cancer provides support for the basic and preclinical research of esophageal cancer,which is of great significance for further study to clarify the pathogenesis and explore the development of new therapeutic drugs.At present,the animal models commonly used in the study of esophageal squamous cell carcinoma mainly include chemical induction model,heterotopic transplantation model and orthotopic transplantation model.With the continuous progress of animal research on human origin tumor,the human transplanted tumor model has been more and more widely used.No matter which model has its own advantages and disadvantages and applicability,should be selected according to the purpose of the experiment.In this paper,the research progress on animal models of esophageal squamous cell carcinoma in recent years is reviewed,and the models commonly used in scientific research and preclinical treatment are discussed,which may provide a theoretical basis for the clinical treatment.

关 键 词：食管肿瘤 模型 动物 诱发性 移植性 食管癌细胞系 

分 类 号：R735.1[医药卫生—肿瘤] R-332[医药卫生—临床医学]