Rh-Catalyzed Formal[3+2]Cyclization for the Synthesis of 5-Aryl-2-(quinolin-2-yl)oxazoles and Its Applications in Metal lons Probes  

作　　者：Tongtong Zhou Xinwei He Youpeng Zuo Yuhao Wu Wangcheng Hu Shiwen Zhang Jiahui Duan Yongjia Shang 

机构地区：[1]Key Laboratory of Functional Molecular Solids,Ministry of Education,Anhui Laboratory of Molecule-Based Materials(State Key Laboratory Cultivation Base),College of Chemistry and Materials Science,Anhui Normal University,Wuhu,Anhui 241002,China

出　　处：《Chinese Journal of Chemistry》2021年第3期621-626,共6页中国化学（英文版）

基　　金：the National Natural Sci-ence Foundation of China(No.21772001);the Anhui Provincial Natural Science Foundation(No.1808085MB41);the Cultiva-tion Project for University Outstanding Talents of Anhui Province(2019).

摘　　要：Main observation and conclusion A facile and efficient strategy for the synthesis of 5-aryl-2-(quinolin-2-yl)oxazoles via rhodium-catalyzed formal[3+2]cyclization of 4-aryl-1-tosyl-1H-1,2,3-triazoles with quinoline-2-carbaldehydes has been described.The protocol employs mild conditions and offers good yields of diverse 2,5-aryloxazole derivatives with a broad reaction scope.It is amenable to gram-scale synthesis and easily transformation.Moreover,this 5-aryl-2-(quinolin-2-yl)oxazole skeleton is indeed a new fluorophore and its applications in metal ions probes are also investigated and showed fluorescent responses to mercury ion.

关 键 词：2-(Quinolin-2-yl)oxazoles CYCLIZATION Metal ions probes CARBENE TRIAZOLES 

分 类 号：O62[理学—有机化学]