Degeneration Versus Development: Hunting-Out the D-Unit of Huntington's Disease  

作　　者：Shengyi Lu Boxun Lu 

机构地区：[1]State Key Laboratory of Medical Neurobiology and Ministry of Education Frontiers Center for Brain Science,School of Life Sciences,Fudan University,Shanghai 200032,China

出　　处：《Neuroscience Bulletin》2021年第5期757-760,共4页神经科学通报（英文版）

摘　　要：Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder caused by a CAG trinucleotide repeat expansion exceeding a threshold length (>35repeats) in exon 1 of the huntingtin gene (HTT)[1]. The age at onset is typically 40–50 years, except for a very low percentage (approximately 6%) of juvenile-onset HD patients carrying 75 or more CAG repeats;longer CAG repeats predict an earlier onset [1].

关 键 词：HUNTINGTON EXCEEDING typically 

分 类 号：R742.2[医药卫生—神经病学与精神病学]