Receptor for advanced glycation end-products axis and coronavirus disease 2019 in inflammatory bowel diseases:A dangerous liaison?  

作　　者：Armando Rojas Ivan Schneider Cristian Lindner Ileana Gonzalez Miguel Angel Morales 

机构地区：[1]Medicine Faculty,Catholic University of Maule,Talca 3634000,Chile [2]Department of Molecular and Clinical Pharmacology Program,Institute of Biomedical Sciences,University of Chile,Santiago 8320000,Chile

出　　处：《World Journal of Gastroenterology》2021年第19期2270-2280,共11页世界胃肠病学杂志（英文版）

摘　　要：Compelling evidence supports the crucial role of the receptor for advanced glycation end-products(RAGE)axis activation in many clinical entities.Since the beginning of the coronavirus disease 2019 pandemic,there is an increasing concern about the risk and handling of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection in inflammatory gastrointestinal disorders,such as inflammatory bowel diseases(IBD).However,clinical data raised during pandemic suggests that IBD patients do not have an increased risk of contracting SARS-CoV-2 infection or develop a more severe course of infection.In the present review,we intend to highlight how two potentially important contributors to the inflammatory response to SARS-CoV-2 infection in IBD patients,the RAGE axis activation as well as the cross-talk with the renin-angiotensin system,are dampened by the high expression of soluble forms of both RAGE and the angiotensin-converting enzyme(ACE)2.The soluble form of RAGE functions as a decoy for its ligands,and soluble ACE2 seems to be an additionally attenuating contributor to RAGE axis activation,particularly by avoiding the transactivation of the RAGE axis that can be produced by the virus-mediated imbalance of the ACE/angiotensin II/angiotensin II receptor type 1 pathway.

关 键 词：COVID-19 Inflammatory bowel diseases Advanced glycation Angiotensinconverting enzyme 2 ALARMINS Receptor for advanced glycation end-products Receptor for advanced glycation end-products axis Inflammation 

分 类 号：R574[医药卫生—消化系统]