Clinical characteristics and outcomes of patients with hepatic angiomyolipoma:A literature review  

作　　者：Paul Calame Gaelle Tyrode Delphine Weil Verhoeven Sophie Felix Anne Julia Klompenhouwer Vincent Di Martino Eric Delabrousse Thierry Thevenot 

机构地区：[1]Department of Radiology,Jean Minjoz University Hospital,Besançon 25030,France [2]Department of Hepatology,Jean Minjoz University Hospital,Besançon 25030,France [3]Department of Pathology,Jean Minjoz University Hospital,Besançon 25000,France [4]Department of Surgery,Erasmus University Medical Center,Rotterdam PO Box 2040,The Netherlands

出　　处：《World Journal of Gastroenterology》2021年第19期2299-2311,共13页世界胃肠病学杂志（英文版）

摘　　要：First reported in 1976,hepatic angiomyolipoma(HAML)is a rare mesenchymal liver tumor occurring mostly in middle-aged women.Diagnosis of the liver mass is often incidental on abdominal imaging due to the frequent absence of specific symptoms.Nearly 10%of HAMLs are associated with tuberous sclerosis complex.HAML contains variable proportions of blood vessels,smooth muscle cells and adipose tissue,which renders radiological diagnosis hazardous.Cells express positivity for HMB-45 and actin,thus these tumors are integrated into the group of perivascular epithelioid cell tumors.Typically,a HAML appears on magnetic resonance imaging(or computed tomography scan)as a hypervascular solid tumor with fatty areas and with washout,and can easily be misdiagnosed as other liver tumors,particularly hepatocellular carcinoma.The therapeutic strategy is not clearly defined,but surgical resection is indicated for symptomatic patients,for tumors showing an aggressive pattern(i.e.,changes in size on imaging or high proliferation activity and atypical epithelioid pattern on liver biopsy),for large(>5 cm)biopsy-proven HAML,and if doubts remain on imaging or histology.Conservative management may be justified in other conditions,since most cases follow a benign clinical course.In summary,the correct diagnosis of HAML is challenging on imaging and relies mainly on pathological findings.

关 键 词：ANGIOMYOLIPOMA LIVER Tuberous sclerosis complex Imaging PATHOLOGY Potentially malignant 

分 类 号：R735.7[医药卫生—肿瘤]