Research progress on the mechanism of evodiamine against gastrointestinal tumor  

作　　者：Chun-Jiao Fan Peng Huang Gui-Hua Huang Hua Qiu Xiao-Mei Zhang 

机构地区：[1]Graduate School of Guangxi University of Chinese Medicine,Nanning 530001,China [2]The Hospital of Guangxi University of Chinese Medicine,Nanning 530023,China

出　　处：《Journal of Hainan Medical University》2021年第10期61-66,共6页海南医学院学报（英文版）

基　　金：National Natural Science Foundation of China(No.81660827);Huang Guihua inheritance Studio Construction Project of famous traditional Chinese Medicine of Guangxi University of traditional Chinese Medicine(No.[2017]2)。

摘　　要：Evodiamine is an indole quinazoline alkaloid with anti-tumor activity,which may be developed into a drug for the treatment of tumor.It was found that evodiamine could inhibit or even block the signal pathways of Wnt/β-catenin,mTOR,NF--κB,PI3K/AKT,Hippo-YAP and BMP in many kinds of cancer cells,thus interfering with cell division and differentiation,increasing the rate of apoptosis,and down-regulating the expression of various cancer cell markers.Such as B-cell lymphoma 2(Bcl-2),B-cell lymphoma super-large(Bcl-XL),cyclooxygenase 2(COX-2),Survivin,vascular endothelial growth factor(VEGF)and matrix metallopeptidase 9(MMP-9),which have a strong inhibitory effect on asymmetric division,malignant proliferation and angiogenesis of tumor cells.This paper summarizes evodiamine in digestive system tumors by regulating Wnt/β-catenin,mTOR,PI3K/AKT,BMP and other signal pathways,interfering with cell division,differentiation and apoptosis,inhibiting the expression of tumor-related marker genes,and preventing tumor cell migration and invasion,so as to provide a basis for the clinical application and further research of evodiamine in the future.

关 键 词：EVODIAMINE Anti-gastrointestinal tumor MECHANISM Cell cycle Apoptosis 

分 类 号：R73[医药卫生—肿瘤]