Mechanism of dopamine binding and allosteric modulation of the human D1 dopamine receptor  

作　　者：Youwen Zhuang Brian Krumm Huibing Zhang X.Edward Zhou Yue Wang Xi-Ping Huang Yongfeng Liu Xi Cheng Yi Jiang Hualiang Jiang Cheng Zhang Wei Yi Bryan L.Roth Yan Zhang H.Eric Xu 

机构地区：[1]The CAS Key Laboratory of Receptor Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China [2]University of Chinese Academy of Sciences,Beijing 100049,China [3]Department of Pharmacology,University of North Carolina at Chapel Hill,Chapel Hill,NC 27599-7365,USA [4]Department of Biophysics and Department of Pathology of Sir Run Run Shaw Hospital,Zhejiang University School of Medicine,Hangzhou,Zhejiang 310058,China [5]MOE Frontier Science Center for Brain Research and Brain-Machine Integration,Zhejiang University School of Medicine,Hangzhou,Zhejiang 310058,China [6]Center for Cancer and Cell Biology,Program for Structural Biology,Van Andel Research Institute,Grand Rapids MI,USA [7]State Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China [8]Department of Pharmacology and Chemical Biology,School of Medicine,University of Pittsburgh,Pittsburgh,PA 15213,USA [9]Key Laboratory of Molecular Target&Clinical Pharmacology,and State Key Laboratory of Respiratory Disease,School of Pharmaceutical Sciences,Guangzhou Medical University,Guangzhou,Guangdong 511436,China [10]Liangzhu Laboratory,Zhejiang University Medical Center,Hangzhou,Zhejiang 311121,China

出　　处：《Cell Research》2021年第5期593-596,共4页细胞研究（英文版）

基　　金：This work was partially supported by the National Key R&D Programs of China(2018YFA0507002),Shanghai Municipal Science and Technology Major Project(2019SHZDZX02);the Strategic Priority Research Program of Chinese Academy of Sciences(XDB37030103)to H.E.X.;the National Natural Science Foundation of China(81922071);the National Key Basic Research Program of China(2019YFA0508800);Zhejiang Province Natural Science Fund for Excellent Young Scholars(LR19H310001);the Fundamental Research Funds for the Central Universities(2019XZZX001-01-06)to Y.Zhang.;Science and Technology Commission of Shanghai Municipal(20431900100);Jack Ma Foundation(2020-CMKYGG-05)to H.J.;the National Natural Science Foundation of China(31770796);National Science and Technology Major Project(2018ZX09711002)to Y.J.;grants from the NIMH Psychoactive Drug Screening Program(to X.P.H.,L.Y.,B.L.R.);RO1MH112205 to B.K.and B.L.R.;NIH grant(R35GM128641)to C.Z.

摘　　要：Dear Editor,Dopamine acts as an essential neurotransmitter whose signaling is conducted through five G protein-coupled receptors(GPCRs),dopamine D1 to D5 receptors(DRD1–DRD5).1 The D1-like receptors,comprising DRD1 and DRD5,primarily couple to the Gs family of G proteins to activate adenylyl cyclase and induce cAMP production.DRD1 is the most abundantly expressed dopamine receptor in the CNS.1 It is the central receptor mediating excitatory dopamine signaling in multiple dopaminergic pathways.Dysregulation of DRD1 signaling has been directly linked to Parkinson’s disease(PD),schizophrenia,and drug abuse.

关 键 词：DOPAMINE DOPAMINE DRD1 

分 类 号：R741[医药卫生—神经病学与精神病学]