植物木酚素生物转化研究进展  

Research progress in biotransformation of plant lignans

作　　者：冯程程 张雯 蔡子哲[1,2] 李颖 汪勇[1,2] 张宁[1,2] FENG Chengcheng;ZHANG Wen;CAI Zizhe;LI Ying;WANG Yong;ZHANG Ning(Department of Food Science and Engineering,Jinan University,Guangzhou 510632,China;Jinan University-Saskatchewan Oilseed Joint Laboratory,Guangzhou 510632,China;School of Nursing,Yichun Vocational and Technical College,Yichun 336000,China)

机构地区：[1]暨南大学食品科学与工程系,广东广州510632 [2]暨南大学-萨斯喀彻温大学“油料生物炼制与营养”联合实验室,广东广州510632 [3]宜春职业技术学院护理学院,江西宜春336000

出　　处：《食品与发酵工业》2021年第11期295-302,共8页Food and Fermentation Industries

基　　金：国家重点研发计划政府间国际创新合作重点专项项目(2018YFE0108400);广州市科技计划项目民生科技攻关计划(201903010049)项目。

摘　　要：植物雌激素是植物中发现或源自植物前体的弱雌激素,在结构上与内源性雌激素相似,同时具有雌激素作用和抗雌激素作用。木酚素是一种植物雌激素,存在于亚麻籽等种子、蔬菜、水果、饮料等日常食品中。膳食木酚素及其衍生代谢物有抗氧化、抗恶性细胞增生等功能,可预防乳腺癌和前列腺癌,心血管疾病,糖尿病等。膳食木酚素生物利用度低,必须被肠道菌群转化为哺乳动物木酚素,如肠二醇和肠内酯,才能发挥其有益作用,膳食木酚素的转化是由人类肠道内优势菌群和亚优势菌群的作用造成的。因此,体外转化膳食木酚素可以提高其生物利用度。比起化学合成法,生物转化法是从膳食木酚素中大量生产哺乳动物木酚素,是一种非常经济、高效和环保的方法。该文简述了木酚素的结构、种类和分布,探讨了木酚素肠道微生物代谢机制,对体外木酚素微生物和酶法转化的研究进展进行了综述。Phytoestrogens are weak oestrogens found in plants or derived from plant precursors.They are structurally similar to endogenous oestrogens which can have both oestrogenic and anti-oestrogenic effects.Lignans are phytoestrogens found in seeds such as flaxseeds,vegetables,fruits,beverages,and other daily foods.Dietary lignans and their derived metabolites have antioxidant,anti-malignant cell proliferation,estrogen-like properties and other functions,and can prevent breast and prostate cancer,cardiovascular diseases and diabetes.Due to their low bioavailability,dietary lignans must be converted into enterolignans such as enterodiol(END)and enterolactone(ENL)to exert their beneficial effects.The conversion of dietary lignans results from the activities of both dominant and subdominant anaerobic bacterial communities in the human intestinal tract.Therefore,the bioavailability of dietary lignans can be improved by transforming them in vitro.Biotransformation is a much more economical,efficient and environmentally friendly method of mass production of enterolignans from dietary lignans than chemical synthesis.The structure,species and distribution of lignans were briefly described,and the intestinal microbial metabolism mechanism of lignans were discussed,as well as the research progress of microbial and enzymatic transformation of lignans in vitro were reviewed.

关 键 词：植物雌激素 木酚素 生物转化 肠二醇 肠内酯 

分 类 号：TS201.2[轻工技术与工程—食品科学]