血管紧张素转换酶抑制肽定量构效关系研究进展  

Research progress on quantitative structure-activity relationship of angiotensin converting enzyme inhibitory peptide

作　　者：杨琦 杨许花[1,2] 杨雪妍 杨扬 马烨杰 程子天 高丹丹 YANG Qi;YANG Xuhua;YANG Xueyan;YANG Yang;MA Yejie;CHENG Zitian;GAO Dandan(College of Life Science and Engineering,Northwest Minzu University,Lanzhou 730030,China;China-Malaysia National Joint Laboratory,Biomedical Research Center,Lanzhou 730124,China)

机构地区：[1]西北民族大学生命科学与工程学院,甘肃兰州730030 [2]西北民族大学生物医学研究中心中国-马来西亚国家联合实验室,甘肃兰州730124

出　　处：《中国酿造》2021年第6期23-27,共5页China Brewing

基　　金：国家自然科学基金项目(31960461);西北民族大学本科生科研创新项目(XBMU-BYL20094)。

摘　　要：在血压调节方面,血管紧张素转换酶(ACE)的活性是重要的影响因子。ACE抑制肽具有抑制ACE活性、降低血压等作用。其毒副作用小、安全性高。该文主要对血压调节机制、ACE抑制肽的降压机理、食源性ACE抑制肽的制备以及定量构效关系进行综述介绍,对指导ACE抑制肽的分子设计过程给予理论分析,有望开发出高活性的功能性食品及降血压药物。In the aspect of blood pressure regulation,the activity of angiotensin converting enzyme(ACE)is an important influencing factor.ACE inhibitory peptide has the function of inhibiting ACE activity and lowering blood pressure.Its toxicity and side effects are small and safety is high.In this paper,the mechanism of blood pressure regulation,the antihypertensive mechanism of ACE inhibitory peptides,the preparation of foodborne ACE inhibitory peptides and the quantitative structure-activity relationship were reviewed and introduced,and the molecular design process of ACE inhibitory peptides was theoretically analyzed,which is expected to develop highly active functional foods and antihypertensive drugs.

关 键 词：高血压 血管紧张素转换酶抑制肽 制备方法 定量构效关系 研究进展 

分 类 号：TQ931[化学工程]