苦瓜皂苷与南瓜多糖或苦荞黄酮联合作用对高脂血症大鼠糖脂代谢的影响  

Effect of bitter melon saponins with pumpkin polysaccharides or buckwheat flavones on glucose and lipid metabolism in hyperlipidemia rats

作　　者：郭怡 李毅腾 吴海清 王步江 肖萍 刘金福 Guo Yi;Li Yiteng;Wu Haiqing;Wang Bujiang;Xiao Ping;Liu Jinfu(College of Food Science and Bioengineering,Tianjin Agricultural University,Tianjin 300392,China;Tianjin Engineering and Technology Research Center of Agricultural Products Processing,Tianjin 300392,China)

机构地区：[1]天津农学院食品科学与生物工程学院,天津300392 [2]天津市农副产品深加工技术工程中心,天津300392

出　　处：《天津农学院学报》2021年第2期51-55,共5页Journal of Tianjin Agricultural University

基　　金：天津市教委科研计划项目(2019KJ036);天津市科技支撑计划重点项目(13ZCZDNC01800)。

摘　　要：采用单维统计分析结合主成分分析法,研究苦瓜皂苷与南瓜多糖或苦荞黄酮联合作用对高脂血症大鼠糖脂代谢的改善作用。结果表明:苦瓜皂苷和南瓜多糖联合作用对胆固醇(TC)、游离脂肪酸(FFA)、肌酐(CRE)和瘦素(LP)改善作用优于单一提取物(P<0.05);在胆固醇(TC)、肌酐(CRE)和游离脂肪酸(FFA)改善效果方面,苦瓜皂苷和苦荞黄酮联合作用同样显著优于各单一提取物(P<0.05)。PCA分析也证实了联合作用对高脂血症有着更加显著的改善作用,且多种活性成分联合使用还可能是通过作用不同的靶点通路起到增效或协同的作用。The effects of bitter melon(Momordica charantia)saponins,pumpkin(Cucurbita moschata)polysaccharides and buckwheat(Fagopyrum tataricum)flavones on glucose and lipid metabolism in hyperlipidemic rats were studied by singledimensional statistical analysis combined with principal component analysis.The results showed that combined bitter melon saponins and pumpkin polysaccharide significantly improved levels of TC,FFA,CRE and LP compared with that of individual extracts(P<0.05).Bitter melon saponin and buckwheat flavones improved effect of TC,CRE and FFA significantly better than that of single component(P<0.05).PCA analysis also confirmed that the combined effect of active ingredients produced more improvement of glucose and lipid metabolism in hyperlipidemic rats by acting on different target pathways.

关 键 词：苦瓜皂苷 南瓜多糖 苦荞黄酮 高脂血症 糖脂代谢 联合作用 

分 类 号：TS255.1[轻工技术与工程—农产品加工及贮藏工程]