Peroxidase-mimicking evodiamine/indocyanine green nanoliposomes for multimodal imaging-guided theranostics for oral squamous cell carcinoma  

作　　者：Zheng Wei Huihui Zou Gongyuan Liu Chuanhui Song Chuanchao Tang Sheng Chen Guorong Zhang Jianchuan Ran Yufeng Wang Xiteng Yin Yu Cai Wei Han 

机构地区：[1]Department of Oral and Maxillofacial Surgery,Nanjing Stomatological Hospital,Medical School of Nanjing University,30 Zhongyang Road,210008,Nanjing,China [2]Clinical Research Institute,Zhejiang Provincial People’s Hospital,People’s Hospital of Hangzhou Medical College,No.158 Shangtang Road,Hangzhou,310014,Zhejiang Province,China [3]Pediatric Dentistry,Nanjing Stomatology Hospital,Medical School of Nanjing University,No 30 Zhongyang Road,Nanjing,210008,China [4]Department of Orthodontics,Nanjing Stomatological Hospital,Medical School of Nanjing University,No 30 Zhongyang Road,Nanjing,210008,China [5]Central Laboratory of Stomatology,Nanjing Stomatological Hospital,Medical School of Nanjing University,30 Zhongyang Road,210008,Nanjing,China [6]Department of Oral Pathology,Nanjing Stomatological Hospital,Medical School of Nanjing University,Nanjing,China [7]Department of Chemistry,City University of Hong Kong,83 Tat Chee Avenue,Hong Kong SAR,China

出　　处：《Bioactive Materials》2021年第7期2144-2157,共14页生物活性材料（英文）

基　　金：This work was supported by Jiangsu provincial natural science foundation(BK20180136,BK20180138,BK20191121);Project of invigorating health care through science,technology and education Jiangsu provincial medical youth talent(QNRC2016121);Nanjing clinical research center for oral diseases(NO.2019060009).

摘　　要：Here,evodiamine(EVO)and the photosensitizer indocyanine green(ICG)were integrated into a liposomal nanoplatform for noninvasive diagnostic imaging and combinatorial therapy against oral squamous cell carcinoma(OSCC).EVO,as an active component extracted from traditional Chinese medicine,not only functioned as an antitumor chemotherapeutic agent but was also capable of 68Ga-chelation,thus working as a contrast agent for positron emission tomography/computed tomography(PET/CT)imaging.Moreover,EVO could exhibit peroxidase-like catalytic activity,converting endogenous tumor H2O2 into cytotoxic reactive oxygen species(ROS),enabling Chemo catalytic therapy beyond the well-known chemotherapy effect of EVO.As proven by in vitro and in vivo experiments,guided by optical imaging and PET/CT imaging,we show that the theragnostic liposomes have a significant inhibiting effect on in situ tongue tumor through photodynamic therapy combined with chemodynamic chemotherapy.

关 键 词：Oral squamous cell carcinoma EVODIAMINE Peroxidase-mimicking Trimodal antitumor therapy 

分 类 号：R739.8[医药卫生—肿瘤]