Repair calvarial defect of osteoporotic rats by berberine functionalized porous calcium phosphate scaffold  

作　　者：Dahao Wang Peng Zhang Xifan Mei Zhenhua Chen 

机构地区：[1]Liaoning University of Traditional Chinese Medicine,Shenyang 110847,China [2]Jinzhou Medical University,Jinzhou 121001,China

出　　处：《Regenerative Biomaterials》2021年第3期84-93,共10页再生生物材料（英文版）

基　　金：This work was supported by National Natural Science Foundation of China(No.81771987,82072076,82072165 and 81871556);Young Top Talents in Xing Liao Talents Program of Liaoning Province(XLYC1807183).

摘　　要：In this article,we propose a simple scheme of using berberine(BBR)to modify porous calcium phosphate ceramics(named PCPC).These BBR molecules regulate the crystallization of hydroxyapatite nanorods on PCPC.We found that these nanorods and the adsorbed BBR changed the interface micro-environment of PCPC by SEM images.The microenvironment of PCPC surface is essential for promoting BMSCs’proliferation and differentiation.These results demonstrated that PCPC/BBR markedly improved the bone regeneration of osteoporosis rats.Moreover,PCPC/BBR had significantly increased the expression levels of ALP,osteocalcin and bone morphogenetic protein2 and RUNX2 in BMSCs originated from osteoporosis rats.

关 键 词：BERBERINE porous ceramics BMSCS OSTEOPOROSIS 

分 类 号：R318[医药卫生—生物医学工程]