尿胰蛋白酶原-2和淀粉酶、脂肪酶联合检测在急性胰腺炎诊断中的价值  

Value of combined detection of urinary trypsinogen-2,amylase and lipase in the diagnosis of acute pancreatitis

作　　者：瞿俊[1] 罗康 QU Jun;LUO Kang(Department of Clinical Laboratory,People's Hospital of Ba'nan District in Chongqing City,Chongqing 401320,China)

机构地区：[1]重庆市巴南区人民医院检验科,重庆401320

出　　处：《中国医药科学》2021年第11期149-152,共4页China Medicine And Pharmacy

摘　　要：目的探讨尿胰蛋白酶原-2(TPS-2)、血清淀粉酶(SAMY)、尿淀粉酶(UAMY)和脂肪酶(LPS)联合检测在急性胰腺炎中的诊断价值。方法选择2019年6—12月在本院就诊的急腹症患者,其中70例为急性胰腺炎患者(AP组),130例为非急性胰腺炎急腹症患者(非AP组),同时选取同期在本院体检中心体检的健康体检者150例为对照组。分别检测三组TPS-2、SAMY、UAMY、LPS水平并进行比较,并比较4种指标单独检测与联合检测对AP的诊断价值。结果AP组的TPS-2阳性率和SAMY、UAMY、LPS水平均显著高于非AP组(P<0.05),AP组和对照组比较,差异有统计学意义(P<0.05)。TPS-2、SAMY、UAMY、LPS联合诊断AP的灵敏度、特异度、准确度分别为92.86%、89.23%、78.58%,明显高于单纯SAMY诊断的75.71%、86.15%、74.32%,UAMY诊断的71.43%、81.54%、72.68%,LPS诊断的81.43%、73.08%、69.89%,TPS-2诊断的91.43%、80.77%、73.28%,差异有统计学意义(P<0.05)。结论联合检测TPS-2、SAMY、UAMY、LPS可为急性胰腺炎与急腹症的鉴别诊断提供依据。四者联合检测可提高AP诊断的灵敏度、特异度、准确度,在AP诊断中具有重要价值,值得在临床应用中推广。Objective To investigate the diagnostic value of combined detection of urinary trypsinogen-2(TPS-2),serum amylase(SAMY),urinary amylase(UAMY)and lipase(LPS)i n acute pancreatitis.Methods Patients with acute abdominal pain treated in our hospital from June to December 2019 were selected,and they were divided into the AP group(patients with acute pancreatitis,n=70),the non-AP group(patients with acute abdominal pain,but without acute pancreatitis,n=130)and the control group(healthy people undergoing physical examination in our examination center in the same period,n=150).The levels of TPS-2,SAMY,UAMY and LPS in three groups were detected separately and compared,and the diagnostic values for AP with the four detection indices respectively or combined were compared.Results The positive rate of TPS-2 and the levels of SAMY,UAMY and LPS in the AP group were all significantly higher than those in the non-AP group(P<0.05).And the differences between the AP group and the control group were statistically significant(P<0.05).The sensitivity,specificity and accuracy of TPS-2,SAMY,UAMY and LPS in the diagnosis of AP were 92.86%,89.23%and 78.58%,respectively,which were significantly higher than 75.71%,86.15%and 74.32%of SAMY respectively,71.43%,81.54%and 72.68%of UAMY respectively,81.43%,73.08%and 69.89%of LPS respectively and 91.43%,80.77%and 73.28%of TPS-2 respectively,with statistically significant differences(P<0.05).Conclusion Combined detection of TPS-2,SAMY,UAMY and LPS can provide evidence for differential diagnosis between acute pancreatitis and acute abdominal pain.Combined detection of the four indices can improve the sensitivity,specificity and accuracy of AP diagnosis,which has important value in AP diagnosis and is worthy of promotion in clinical ap plication.

关 键 词：尿胰蛋白酶原-2 淀粉酶 脂肪酶 急性胰腺炎 

分 类 号：R576[医药卫生—消化系统] R446.6[医药卫生—内科学]