Factors Affecting Catecholamines in Caregivers of Patients with De­mentia  

作　　者：Akemi Hirano Yusuke Suzuki Toshio Hayashi Koichiro Ina Joji Onishi 

机构地区：[1]Department of Adult Nursing,Shubun University,6 Nikko-cho,Ichinomiya,Aichi 491-0938,Japan [2]Centre for Community Liaison and Patient Consultations,Nagoya University Hospital,65 Tsuruma,Showa,Nagoya,Aichi 466-8550,Japan [3]Department of Community and In-Home Nursing,Nagoya University Graduate School of Medicine,School of Health Sciences,Daiko-Minami,Higashi-ku,Nagoya,Aichi 461-8673,Japan [4]Department of Internal Medicine,Ina Clinic,3-111 Hirabari,Tenpaku,Nagoya,Aichi 468-0011,Japan [5]Department of Community Healthcare&Geriatrics,Nagoya University Graduate School of Medicine,65 Tsuruma,Showa,Nagoya,Aichi 466-8550,Japan

出　　处：《Journal of Geriatric Medicine》2021年第1期32-37,共6页老年医学（英文）

摘　　要：Background:Caregivers of dementia patients have significantly higher levels of serum IL-6 and CRP compared to non-caregivers,and the ac­cumulation of everyday stressors reportedly promotes the induction of inflammatory markers.However,few studies have identified factors that affect catecholamine levels in caregivers who experience a combination of physical and mental stress from caregiving.Purpose:This study aimed to identify physical factors that impact catecholamine levels in caregivers of dementia patients.Methods:Participants were elderly caregivers living together with elderly Alzhei­mer’s-type dementia patients.We performed logistic regression analysis,with levels of adrenaline,noradrenaline,and dopamine(indicators of catecholamine)as dependent variables.Results:Caregiver BMI had a significant impact on adrenaline levels(OR:0.792;95%CI:0.654-0.960)and noradrenaline levels(OR:1.210;95%CI:1.009-1.451),whereas age had a significant impact on dopamine levels(OR:1.162;95%CI:1.019-1.324).Discussion:While caregiver BMI significantly impacted adrenaline and noradrenaline levels,the mechanism underlying these relationships is unclear.One possibility is that obesity(BMI)and a rise in sympathetic nerve activity contributed to hypertension.Our findings suggest that chronic stress in elderly caregivers may potentially impair the dopaminergic activation system in the brain.Conclusion:There is a need to identify factors which increase BMI in caregivers.Future studies aimed at gaining a better understanding of the lifestyle habits of caregiv­ers and intervention studies aimed at reducing their BMI are warranted.

关 键 词：Age BMI Caregiver burden CATECHOLAMINE DEMENTIA 

分 类 号：R74[医药卫生—神经病学与精神病学]